45507

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2433298..2433775 Replicon chromosome
Accession NZ_CP006740
Organism Xylella fastidiosa MUL0034

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag P303_RS11220 Protein ID WP_011097988.1
Coordinates 2433509..2433775 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag P303_RS11215 Protein ID WP_004091377.1
Coordinates 2433298..2433525 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P303_RS11185 2429015..2429392 + 378 WP_038228427.1 DUF596 domain-containing protein -
P303_RS11190 2429622..2430806 + 1185 Protein_2200 DUF769 domain-containing protein -
P303_RS13190 2430858..2431298 + 441 WP_162832852.1 hypothetical protein -
P303_RS11195 2431295..2431669 + 375 WP_038228431.1 hypothetical protein -
P303_RS11200 2431801..2432181 + 381 WP_038228433.1 DUF596 domain-containing protein -
P303_RS11210 2432649..2433187 - 539 Protein_2204 hypothetical protein -
P303_RS11215 2433298..2433525 + 228 WP_004091377.1 hypothetical protein Antitoxin
P303_RS11220 2433509..2433775 + 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P303_RS11225 2433786..2435180 - 1395 WP_040123316.1 hypothetical protein -
P303_RS11250 2436372..2437133 + 762 WP_004085598.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T45507 WP_011097988.1 NZ_CP006740:2433509-2433775 [Xylella fastidiosa MUL0034]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T45507 NZ_CP006740:2433509-2433775 [Xylella fastidiosa MUL0034]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT45507 WP_004091377.1 NZ_CP006740:2433298-2433525 [Xylella fastidiosa MUL0034]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT45507 NZ_CP006740:2433298-2433525 [Xylella fastidiosa MUL0034]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References