Detailed information of TA system TA045506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1931884..1932495
• Replicon: chromosome
• Accession: NZ_CP006740
• Organism: Xylella fastidiosa MUL0034

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060HHU8
• Locus tag: P303_RS09020
• Protein ID: WP_024749166.1
• Coordinates: 1931884..1932183 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q879U0
• Locus tag: P303_RS09025
• Protein ID: WP_004085003.1
• Coordinates: 1932187..1932495 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P303_RS08980	1926998..1928143	-	1146	WP_011097984.1	baseplate J/gp47 family protein	-
P303_RS08985	1928246..1928542	+	297	WP_004085590.1	type II toxin-antitoxin system RelE/ParE family toxin	-
P303_RS08990	1928545..1928838	+	294	WP_004085592.1	putative addiction module antidote protein	-
P303_RS08995	1928894..1929247	-	354	WP_040123277.1	hypothetical protein	-
P303_RS09000	1929244..1929885	-	642	WP_040123250.1	hypothetical protein	-
P303_RS09005	1929882..1930712	-	831	WP_038230303.1	hypothetical protein	-
P303_RS09010	1930709..1931026	-	318	WP_012382585.1	hypothetical protein	-
P303_RS09015	1931026..1931796	-	771	Protein_1791	hypothetical protein	-
P303_RS09020	1931884..1932183	+	300	WP_024749166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
P303_RS09025	1932187..1932495	+	309	WP_004085003.1	putative addiction module antidote protein	Antitoxin
P303_RS09030	1932569..1934458	-	1890	WP_038230294.1	hypothetical protein	-
P303_RS09035	1934606..1935028	-	423	WP_004085005.1	hypothetical protein	-
P303_RS09040	1935025..1935462	-	438	WP_040123251.1	DUF3277 family protein	-
P303_RS09045	1935472..1936968	-	1497	WP_038230289.1	DUF3383 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1881168..1989350	108182

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11364.14 Da
• Isoelectric Point: 10.3861

>T45506 WP_024749166.1 NZ_CP006740:1931884-1932183 [Xylella fastidiosa MUL0034]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T45506 NZ_CP006740:1931884-1932183 [Xylella fastidiosa MUL0034]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCAGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11060.61 Da
• Isoelectric Point: 4.6535

>AT45506 WP_004085003.1 NZ_CP006740:1932187-1932495 [Xylella fastidiosa MUL0034]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Nucleotide

• Length: 309 bp

>AT45506 NZ_CP006740:1932187-1932495 [Xylella fastidiosa MUL0034]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCTCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Structures

Toxin

• AlphaFold DB: A0A060HHU8

Antitoxin

• AlphaFold DB: A0A060HCD4