Detailed information of TA system TA045504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1786093..1786704
• Replicon: chromosome
• Accession: NZ_CP006740
• Organism: Xylella fastidiosa MUL0034

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060HHU8
• Locus tag: P303_RS08150
• Protein ID: WP_024749166.1
• Coordinates: 1786093..1786392 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q879U0
• Locus tag: P303_RS08155
• Protein ID: WP_004085003.1
• Coordinates: 1786396..1786704 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P303_RS08110	1781243..1782388	-	1146	WP_011097984.1	baseplate J/gp47 family protein	-
P303_RS08115	1782487..1782783	+	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
P303_RS08120	1782787..1783092	+	306	WP_038211623.1	putative addiction module antidote protein	-
P303_RS08125	1783103..1783456	-	354	WP_040123249.1	hypothetical protein	-
P303_RS08130	1783453..1784094	-	642	WP_040123250.1	hypothetical protein	-
P303_RS08135	1784091..1784921	-	831	WP_038230303.1	hypothetical protein	-
P303_RS08140	1784918..1785235	-	318	WP_012382585.1	hypothetical protein	-
P303_RS08145	1785235..1786005	-	771	Protein_1613	hypothetical protein	-
P303_RS08150	1786093..1786392	+	300	WP_024749166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
P303_RS08155	1786396..1786704	+	309	WP_004085003.1	putative addiction module antidote protein	Antitoxin
P303_RS08160	1786778..1788667	-	1890	WP_038230294.1	hypothetical protein	-
P303_RS08165	1788815..1789237	-	423	WP_004085005.1	hypothetical protein	-
P303_RS08170	1789234..1789671	-	438	WP_040123251.1	DUF3277 family protein	-
P303_RS08175	1789681..1791177	-	1497	WP_038230289.1	DUF3383 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1777388..1827214	49826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11364.14 Da
• Isoelectric Point: 10.3861

>T45504 WP_024749166.1 NZ_CP006740:1786093-1786392 [Xylella fastidiosa MUL0034]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T45504 NZ_CP006740:1786093-1786392 [Xylella fastidiosa MUL0034]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCAGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11060.61 Da
• Isoelectric Point: 4.6535

>AT45504 WP_004085003.1 NZ_CP006740:1786396-1786704 [Xylella fastidiosa MUL0034]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Nucleotide

• Length: 309 bp

>AT45504 NZ_CP006740:1786396-1786704 [Xylella fastidiosa MUL0034]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCTCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Structures

Toxin

• AlphaFold DB: A0A060HHU8

Antitoxin

• AlphaFold DB: A0A060HCD4