Detailed information of TA system TA045502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1307562..1308148
• Replicon: chromosome
• Accession: NZ_CP006740
• Organism: Xylella fastidiosa MUL0034

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: P303_RS05970
• Protein ID: WP_038228269.1
• Coordinates: 1307894..1308148 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2I6C9
• Locus tag: P303_RS05965
• Protein ID: WP_004085025.1
• Coordinates: 1307562..1307897 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P303_RS05935	1303163..1304017	-	855	WP_024749029.1	iron-sulfur cluster carrier protein ApbC	-
P303_RS05940	1304509..1305282	+	774	WP_004089528.1	3-deoxy-manno-octulosonate cytidylyltransferase	-
P303_RS05945	1305279..1305743	+	465	WP_011098056.1	low molecular weight phosphotyrosine protein phosphatase	-
P303_RS05950	1305730..1306444	-	715	Protein_1169	site-specific DNA-methyltransferase	-
P303_RS05955	1306792..1307073	+	282	WP_011098058.1	type II toxin-antitoxin system RelE/ParE family toxin	-
P303_RS05960	1307083..1307382	+	300	WP_004089519.1	HigA family addiction module antidote protein	-
P303_RS05965	1307562..1307897	-	336	WP_004085025.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
P303_RS05970	1307894..1308148	-	255	WP_038228269.1	type II toxin-antitoxin system HicA family toxin	Toxin
P303_RS05975	1308201..1308899	-	699	WP_040123196.1	hypothetical protein	-
P303_RS05980	1309028..1309489	-	462	WP_173391697.1	hypothetical protein	-
P303_RS05985	1309486..1310250	-	765	WP_196242994.1	hypothetical protein	-
P303_RS05990	1310156..1311058	-	903	WP_040123198.1	YdaU family protein	-
P303_RS05995	1311055..1311354	-	300	WP_080679645.1	hypothetical protein	-
P303_RS06000	1311456..1311830	+	375	WP_040123200.1	hypothetical protein	-
P303_RS06005	1311836..1312441	+	606	WP_040123201.1	conjugal transfer protein TrbN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9679.16 Da
• Isoelectric Point: 11.2766

>T45502 WP_038228269.1 NZ_CP006740:c1308148-1307894 [Xylella fastidiosa MUL0034]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSHNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T45502 NZ_CP006740:c1308148-1307894 [Xylella fastidiosa MUL0034]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGACTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCTCATAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12324.07 Da
• Isoelectric Point: 5.6556

>AT45502 WP_004085025.1 NZ_CP006740:c1307897-1307562 [Xylella fastidiosa MUL0034]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Nucleotide

• Length: 336 bp

>AT45502 NZ_CP006740:c1307897-1307562 [Xylella fastidiosa MUL0034]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTTGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Structures

Antitoxin

• AlphaFold DB: A0A060HAK5