Detailed information of TA system TA045501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 1125745..1126418
• Replicon: chromosome
• Accession: NZ_CP006740
• Organism: Xylella fastidiosa MUL0034

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: P303_RS05175
• Protein ID: WP_038230656.1
• Coordinates: 1126014..1126418 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: P303_RS05170
• Protein ID: WP_038230657.1
• Coordinates: 1125745..1126017 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P303_RS05135	1121989..1122297	-	309	WP_004089386.1	type II toxin-antitoxin system RelE/ParE family toxin	-
P303_RS05140	1122306..1122545	-	240	WP_011097871.1	antitoxin	-
P303_RS05145	1122683..1123036	-	354	WP_040123185.1	hypothetical protein	-
P303_RS05150	1123033..1123674	-	642	WP_040123186.1	hypothetical protein	-
P303_RS05155	1123671..1124501	-	831	WP_040123187.1	hypothetical protein	-
P303_RS05160	1124498..1124815	-	318	WP_012382585.1	hypothetical protein	-
P303_RS05165	1124815..1125585	-	771	WP_040123188.1	hypothetical protein	-
P303_RS05170	1125745..1126017	+	273	WP_038230657.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
P303_RS05175	1126014..1126418	+	405	WP_038230656.1	type II toxin-antitoxin system VapC family toxin	Toxin
P303_RS05180	1126437..1128243	-	1807	Protein_1012	hypothetical protein	-
P303_RS13690	1128200..1128364	-	165	WP_196242993.1	hypothetical protein	-
P303_RS05185	1128391..1128813	-	423	WP_038230059.1	hypothetical protein	-
P303_RS05190	1128810..1129247	-	438	WP_004087249.1	DUF3277 family protein	-
P303_RS05195	1129257..1129484	-	228	Protein_1016	DUF3383 family protein	-
P303_RS05200	1129507..1130713	-	1207	Protein_1017	transposase	-
P303_RS05205	1130707..1131313	-	607	Protein_1018	IS607 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1118961..1137435	18474

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14667.97 Da
• Isoelectric Point: 5.6955

>T45501 WP_038230656.1 NZ_CP006740:1126014-1126418 [Xylella fastidiosa MUL0034]
VSGYMLDTNIISDIIRNPFGAVACRIEHVGYPNICTSVIVAAELRYGCTKNGSVKLLSRVQDILKTLPLLPLEIPVDTTY
GSIRAELEAAGQLIGANDLLIAAHAYVLGLTLVTDNTREFSRIRGLDVQNWLER

Nucleotide

• Length: 405 bp

>T45501 NZ_CP006740:1126014-1126418 [Xylella fastidiosa MUL0034]
GTGAGCGGCTATATGCTCGACACGAATATCATCAGCGATATCATTCGTAACCCATTCGGGGCGGTTGCTTGCCGTATTGA
ACACGTTGGGTATCCGAACATTTGCACGAGCGTTATCGTGGCGGCTGAACTTCGCTATGGATGCACGAAAAATGGCTCGG
TAAAGCTGCTGAGCAGGGTACAGGACATTCTTAAAACGCTGCCGCTCCTGCCTTTGGAAATACCTGTTGACACAACATAT
GGCAGTATCCGTGCTGAGCTGGAGGCTGCGGGTCAGCTGATCGGCGCTAATGATCTATTGATTGCTGCGCATGCTTACGT
ACTCGGGCTGACTTTGGTCACGGACAACACCCGCGAGTTCAGCCGAATTCGCGGCTTGGATGTGCAGAACTGGCTAGAGA
GGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10493.00 Da
• Isoelectric Point: 4.7010

>AT45501 WP_038230657.1 NZ_CP006740:1125745-1126017 [Xylella fastidiosa MUL0034]
MPISSPLSRTKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPITRPTNIVELLHEWRRETPLDPEDQFPDID
DMPVQPEDIL

Nucleotide

• Length: 273 bp

>AT45501 NZ_CP006740:1125745-1126017 [Xylella fastidiosa MUL0034]
ATGCCAATTTCATCTCCGTTATCACGTACCAAGGAAGCGAAGCTATTCCGAAATAATCGTAGCCAGGCGGTACGAATTCC
CGTTGAATTCGAGCTGCCGGGCGATCGTGTTCTGATCCACCGTGAGGGGAGCAAGCTCATTATTGAGCCGATCACCAGGC
CAACCAATATTGTTGAATTACTGCACGAGTGGCGAAGAGAAACACCACTCGACCCAGAAGATCAATTCCCTGATATTGAT
GACATGCCCGTTCAGCCAGAGGATATTCTGTGA