Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 839990..840512 Replicon chromosome
Accession NZ_CP006740
Organism Xylella fastidiosa MUL0034

Toxin (Protein)


Gene name parE Uniprot ID A0A060HA53
Locus tag P303_RS03795 Protein ID WP_038229230.1
Coordinates 840225..840512 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag P303_RS03790 Protein ID WP_004085758.1
Coordinates 839990..840232 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P303_RS03750 835423..835749 - 327 WP_004091396.1 DNA-binding protein -
P303_RS03755 835879..836199 - 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
P303_RS03760 836310..836483 - 174 Protein_720 XRE family transcriptional regulator -
P303_RS03765 836660..836950 + 291 WP_038229226.1 BrnT family toxin -
P303_RS03770 836937..837242 + 306 WP_004091409.1 BrnA antitoxin family protein -
P303_RS03775 837579..838484 - 906 WP_040123139.1 AEC family transporter -
P303_RS12480 838495..839394 - 900 WP_140189706.1 TauD/TfdA family dioxygenase -
P303_RS12485 839593..839757 - 165 Protein_725 Tn3 family transposase -
P303_RS03790 839990..840232 + 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
P303_RS03795 840225..840512 + 288 WP_038229230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P303_RS03800 840600..841166 + 567 WP_038229232.1 recombinase family protein -
P303_RS03805 841251..841460 - 210 WP_040123140.1 hypothetical protein -
P303_RS03810 841475..842447 - 973 Protein_730 DNA primase -
P303_RS03815 842635..843633 - 999 WP_004085391.1 MBL fold metallo-hydrolase -
P303_RS03820 843765..844451 - 687 WP_038229254.1 TIGR02453 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 840600..841166 566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11163.63 Da        Isoelectric Point: 5.9570

>T45500 WP_038229230.1 NZ_CP006740:840225-840512 [Xylella fastidiosa MUL0034]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLTDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T45500 NZ_CP006740:840225-840512 [Xylella fastidiosa MUL0034]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGTAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGACGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT45500 WP_004085758.1 NZ_CP006740:839990-840232 [Xylella fastidiosa MUL0034]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT45500 NZ_CP006740:839990-840232 [Xylella fastidiosa MUL0034]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTGCTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HA53

Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References