Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 259047..259578 Replicon chromosome
Accession NZ_CP006740
Organism Xylella fastidiosa MUL0034

Toxin (Protein)


Gene name relE Uniprot ID A0A060HEY7
Locus tag P303_RS01270 Protein ID WP_038230161.1
Coordinates 259297..259578 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A060H9I0
Locus tag P303_RS01265 Protein ID WP_004086967.1
Coordinates 259047..259310 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P303_RS01235 254105..255124 + 1020 WP_038230156.1 tetraacyldisaccharide 4'-kinase -
P303_RS01240 255531..256253 - 723 WP_080679715.1 phage late control D family protein -
P303_RS01245 256138..257109 - 972 WP_040123072.1 hypothetical protein -
P303_RS01250 257117..257674 - 558 WP_040123338.1 phage tail protein I -
P303_RS01255 257667..258560 - 894 WP_040123073.1 baseplate J/gp47 family protein -
P303_RS01260 258560..258898 - 339 WP_004088650.1 GPW/gp25 family protein -
P303_RS01265 259047..259310 + 264 WP_004086967.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P303_RS01270 259297..259578 + 282 WP_038230161.1 type II toxin-antitoxin system YafQ family toxin Toxin
P303_RS01275 259615..260202 - 588 WP_027700438.1 phage baseplate assembly protein V -
P303_RS01280 260199..260741 - 543 WP_040123074.1 hypothetical protein -
P303_RS01285 260717..261238 - 522 WP_038230165.1 hypothetical protein -
P303_RS01290 261235..261558 - 324 WP_027700441.1 hypothetical protein -
P303_RS01295 261558..261818 - 261 WP_027700442.1 hypothetical protein -
P303_RS01300 261836..263710 - 1875 WP_040123075.1 phage major capsid protein -
P303_RS01305 263707..264339 - 633 WP_040123076.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 247706..269756 22050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10834.28 Da        Isoelectric Point: 7.5505

>T45495 WP_038230161.1 NZ_CP006740:259297-259578 [Xylella fastidiosa MUL0034]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVVEALACDHPLEPRHHDHALTGGWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Download         Length: 282 bp

>T45495 NZ_CP006740:259297-259578 [Xylella fastidiosa MUL0034]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTAATACACGTCGTAGAAGCCTTGGCCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTGACTG
GCGGCTGGAAAGATCACCGTGATTGCCACATCAAACCCGATTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9525.98 Da        Isoelectric Point: 5.6033

>AT45495 WP_004086967.1 NZ_CP006740:259047-259310 [Xylella fastidiosa MUL0034]
MSANAVVRARVDTHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp

>AT45495 NZ_CP006740:259047-259310 [Xylella fastidiosa MUL0034]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACACGCACATCAAAGAAGAAGCATCAACCGTGCTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGTATGATGCTGACCCGCATTGCTCGTGAGAAAGCACTACCGTTCGAGCCGCTGGTGC
CGAACGAAACTACCATCGCAGCCATGCGTGAAGCCCGTGCTGGTCACCTCAAGAGCTTTGATAGTATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HEY7

Antitoxin

Source ID Structure
AlphaFold DB A0A060H9I0

References