45490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4682379..4683716 Replicon chromosome
Accession NZ_CP006738
Organism Klebsiella pneumoniae HK787

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag P244_RS23160 Protein ID WP_032424556.1
Coordinates 4682781..4683716 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID -
Locus tag P244_RS23155 Protein ID WP_023302769.1
Coordinates 4682379..4682774 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P244_RS23125 4677623..4677913 + 291 WP_022615704.1 hypothetical protein -
P244_RS23130 4677978..4678883 + 906 WP_022615703.1 DUF1738 domain-containing protein -
P244_RS23135 4679076..4679447 + 372 WP_022615702.1 hypothetical protein -
P244_RS23140 4679621..4681216 + 1596 WP_023302771.1 TraI domain-containing protein -
P244_RS23145 4681388..4681852 + 465 WP_022615700.1 GNAT family N-acetyltransferase -
P244_RS27440 4681858..4682124 - 267 WP_023302770.1 hypothetical protein -
P244_RS23155 4682379..4682774 + 396 WP_023302769.1 hypothetical protein Antitoxin
P244_RS23160 4682781..4683716 + 936 WP_032424556.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P244_RS27445 4683724..4684413 - 690 WP_023302767.1 hypothetical protein -
P244_RS23165 4684613..4685407 - 795 WP_023302766.1 RES domain-containing protein -
P244_RS23170 4685826..4687505 - 1680 WP_004212561.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-298)

Antitoxin

Protein of unknown function DUF6088

(7-109)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35389.66 Da        Isoelectric Point: 5.6165

>T45490 WP_032424556.1 NZ_CP006738:4682781-4683716 [Klebsiella pneumoniae HK787]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Download         Length: 936 bp

>T45490 NZ_CP006738:4682781-4683716 [Klebsiella pneumoniae HK787]
CTGCTTTTTTCTGATGTAACAGATGCTCTTGGTATTGAGTCCGGCGCTATTGTAGAAAAAGATCACTATATCGTTGAGCT
TTTACATTTACTGAAACCGCTAACATTTGACACTCATCAATTGCTGTTTGCCGGAGGAACTGCACTGGCAAAATCGGGCA
TTGTGCTTAACCGAATGTCGGAAGATGTAGATATAAAACTGGTACCCACAGATACTTTCTTGTCTCTTTCGCGCACCCAG
CGCAAAGGTATTCGTAAAGAGATCGTCCAGACAATTTCTCATGCAATAACTGCAACAGACATGTTCAGCTTTGACGATGC
CCATCCAAAAGTGACGCGGGATGAATATCGTTACAACGACATACCCGTTCGCTATCCGCAGCGGGTAGCGCAAGCACCTT
GCCTGCGTCCTTTTATCCAGTTGGAATTGATGGAAGCAAATTTGCTTGAGGCACCAGAGTTCAGGGATATTCATACACTG
GTGACGACACTTACTGGAAAAGCACCTGTCATTTCAGCCTTCCCCTGCGCCACAATTATCAGTACTCAGGCAGAAAAACT
GGTGGCTATGCTGCGCCGTACTGCAGCAGTTGCGCGTAATATTGAACGCCAGGATGACGCTTCGCTGGTACGTCATATCT
ACGACACATATTGTATCGTGCAGGCAGGCAATGTTGATATGTGTTTGCTTACTGATTTTTTTAAGCAAACCATTGAGCAA
GATATCCAGCGTTATGGCAATCAGTATCCGCAGTTTTGTGTTTCACCAAATGATGAGCTAAAAATGGGGCTGGACGAACT
TGAGCATAACCCGCTTTATAAGACACGCTACCAGCAATTTGTTGCCCCAATGGTATATGGTGCTCGCAAGGTATCGTGGG
ATGAAGCGTATGCTTCCTTTCGTCAAATGGCGTTAATAATTCTAGATACTTACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14800.08 Da        Isoelectric Point: 11.1078

>AT45490 WP_023302769.1 NZ_CP006738:4682379-4682774 [Klebsiella pneumoniae HK787]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Download         Length: 396 bp

>AT45490 NZ_CP006738:4682379-4682774 [Klebsiella pneumoniae HK787]
ATGACGATAAAAACACGCATTCAGTCACGACTGAAACGCTCAAAACGCTATGTATTCACTCGTGACGATTTCAAGGATAT
TGCAGGCTATGATCAGATTGGCAGGGTATTGCGCGACCTTCTCAAAGAGGGGCAACTACTGAAGGTGGGCTACGGTGTGT
ACACCAAAGCGCGTCGGAACAGCATTACTGGAAAAGTCATGCCCGCAGCACCAAGGGGATCTTCGGCAGTGATCGTTGAA
ACGCTGGAGCGCCTGAAAGTACGTTACCGCTATGAAGGAGCTACACAGACATATAATAGTGGCGAATCCACGCAAATCCC
CGTGTCACCGGAGATCAAAACATCTCCGCGCTTTAAACGCGCGTTGTCTGTGGGGAACAGCAAACTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References