Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4019400..4020019 Replicon chromosome
Accession NZ_CP006738
Organism Klebsiella pneumoniae HK787

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag P244_RS19920 Protein ID WP_002892050.1
Coordinates 4019801..4020019 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag P244_RS19915 Protein ID WP_002892066.1
Coordinates 4019400..4019774 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P244_RS19905 4014552..4015745 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P244_RS19910 4015768..4018914 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
P244_RS19915 4019400..4019774 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
P244_RS19920 4019801..4020019 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
P244_RS19925 4020178..4020744 + 567 WP_002892030.1 maltose O-acetyltransferase -
P244_RS28645 4020716..4020856 - 141 WP_004147370.1 hypothetical protein -
P244_RS19935 4020877..4021347 + 471 WP_002892026.1 YlaC family protein -
P244_RS19940 4021322..4022773 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
P244_RS19945 4022874..4023572 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
P244_RS19950 4023569..4023709 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
P244_RS19955 4023709..4023972 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4024098..4025162 1064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T45488 WP_002892050.1 NZ_CP006738:4019801-4020019 [Klebsiella pneumoniae HK787]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T45488 NZ_CP006738:4019801-4020019 [Klebsiella pneumoniae HK787]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT45488 WP_002892066.1 NZ_CP006738:4019400-4019774 [Klebsiella pneumoniae HK787]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT45488 NZ_CP006738:4019400-4019774 [Klebsiella pneumoniae HK787]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References