Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1790283..1790873 Replicon chromosome
Accession NZ_CP006738
Organism Klebsiella pneumoniae HK787

Toxin (Protein)


Gene name pemK Uniprot ID A0A2L1BXX2
Locus tag P244_RS08785 Protein ID WP_022615588.1
Coordinates 1790541..1790873 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag P244_RS08780 Protein ID WP_000288812.1
Coordinates 1790283..1790540 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P244_RS08760 1786619..1788367 + 1749 WP_023302666.1 hypothetical protein -
P244_RS26780 1788446..1789002 + 557 Protein_1677 hypothetical protein -
P244_RS08770 1789285..1789745 + 461 Protein_1678 hypothetical protein -
P244_RS08775 1789742..1789948 + 207 WP_022615589.1 helix-turn-helix domain-containing protein -
P244_RS08780 1790283..1790540 + 258 WP_000288812.1 antitoxin Antitoxin
P244_RS08785 1790541..1790873 + 333 WP_022615588.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P244_RS08800 1791195..1792629 + 1435 Protein_1682 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
P244_RS08810 1792995..1794449 - 1455 WP_004148975.1 AMP nucleosidase -
P244_RS08815 1794579..1794824 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11913.80 Da        Isoelectric Point: 10.1839

>T45478 WP_022615588.1 NZ_CP006738:1790541-1790873 [Klebsiella pneumoniae HK787]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

>T45478 NZ_CP006738:1790541-1790873 [Klebsiella pneumoniae HK787]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT45478 WP_000288812.1 NZ_CP006738:1790283-1790540 [Klebsiella pneumoniae HK787]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT45478 NZ_CP006738:1790283-1790540 [Klebsiella pneumoniae HK787]
ATGTATACAACTCGCCTGAAAAAGGTAGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1BXX2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References