Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1285940..1286506 Replicon chromosome
Accession NZ_CP006715
Organism Bifidobacterium breve 689b

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag B689B_RS05475 Protein ID WP_014483710.1
Coordinates 1286213..1286506 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag B689B_RS05470 Protein ID WP_014483711.1
Coordinates 1285940..1286209 (+) Length 90 a.a.

Genomic Context

B689B_RS05450B689B_RS05455B689B_RS05460B689B_RS05465B689B_RS05470B689B_RS05475B689B_RS05485B689B_RS05490B689B_RS05495B689B_RS05500B689B_RS05505B689B_RS05510B689B_RS05445
Location: 1282510..1283025 (516 bp)
Type: Others
Protein ID: WP_013140733.1
Location: 1283022..1283912 (891 bp)
Type: Others
Protein ID: WP_025332287.1
Location: 1283909..1284589 (681 bp)
Type: Others
Protein ID: WP_003829413.1
Location: 1284586..1285755 (1170 bp)
Type: Others
Protein ID: WP_025332288.1
Location: 1285940..1286209 (270 bp)
Type: Antitoxin
Protein ID: WP_014483711.1
Location: 1286213..1286506 (294 bp)
Type: Toxin
Protein ID: WP_014483710.1
Location: 1287175..1287726 (552 bp)
Type: Others
Protein ID: WP_025332289.1
Location: 1287760..1288587 (828 bp)
Type: Others
Protein ID: WP_015438835.1
Location: 1288719..1289345 (627 bp)
Type: Others
Protein ID: WP_025332290.1
Location: 1289342..1290124 (783 bp)
Type: Others
Protein ID: WP_025332291.1
Location: 1290177..1291052 (876 bp)
Type: Others
Protein ID: WP_025332292.1
Location: 1291107..1291505 (399 bp)
Type: Others
Protein ID: WP_003829426.1
Location: 1281689..1282384 (696 bp)
Type: Others
Protein ID: WP_003829410.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B689B_RS054451281689..1282384-696WP_003829410.1response regulator transcription factor-
B689B_RS054501282510..1283025+516WP_013140733.1hypothetical protein-
B689B_RS054551283022..1283912+891WP_025332287.1hypothetical protein-
B689B_RS054601283909..1284589+681WP_003829413.1ABC transporter ATP-binding protein-
B689B_RS054651284586..1285755+1170WP_025332288.1ABC transporter permease-
B689B_RS054701285940..1286209+270WP_014483711.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
B689B_RS054751286213..1286506+294WP_014483710.1type II toxin-antitoxin system YafQ family toxinToxin
B689B_RS054851287175..1287726+552WP_025332289.1RNA polymerase sigma factor-
B689B_RS054901287760..1288587+828WP_015438835.1hypothetical protein-
B689B_RS054951288719..1289345+627WP_025332290.1hypothetical protein-
B689B_RS055001289342..1290124+783WP_025332291.1hypothetical protein-
B689B_RS055051290177..1291052+876WP_025332292.1ABC transporter ATP-binding protein-
B689B_RS055101291107..1291505+399WP_003829426.1superoxide dismutase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1276407..129793321526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T45451 WP_014483710.1 NZ_CP006715:1286213-1286506 [Bifidobacterium breve 689b]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T45451 NZ_CP006715:1286213-1286506 [Bifidobacterium breve 689b]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT45451 WP_014483711.1 NZ_CP006715:1285940-1286209 [Bifidobacterium breve 689b]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT45451 NZ_CP006715:1285940-1286209 [Bifidobacterium breve 689b]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS2ZEY8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0L7C7C8

References