Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1285940..1286506 Replicon chromosome
Accession NZ_CP006715
Organism Bifidobacterium breve 689b

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag B689B_RS05475 Protein ID WP_014483710.1
Coordinates 1286213..1286506 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag B689B_RS05470 Protein ID WP_014483711.1
Coordinates 1285940..1286209 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B689B_RS05445 1281689..1282384 - 696 WP_003829410.1 response regulator transcription factor -
B689B_RS05450 1282510..1283025 + 516 WP_013140733.1 hypothetical protein -
B689B_RS05455 1283022..1283912 + 891 WP_025332287.1 hypothetical protein -
B689B_RS05460 1283909..1284589 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
B689B_RS05465 1284586..1285755 + 1170 WP_025332288.1 ABC transporter permease -
B689B_RS05470 1285940..1286209 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B689B_RS05475 1286213..1286506 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
B689B_RS05485 1287175..1287726 + 552 WP_025332289.1 RNA polymerase sigma factor -
B689B_RS05490 1287760..1288587 + 828 WP_015438835.1 hypothetical protein -
B689B_RS05495 1288719..1289345 + 627 WP_025332290.1 hypothetical protein -
B689B_RS05500 1289342..1290124 + 783 WP_025332291.1 hypothetical protein -
B689B_RS05505 1290177..1291052 + 876 WP_025332292.1 ABC transporter ATP-binding protein -
B689B_RS05510 1291107..1291505 + 399 WP_003829426.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1276407..1297933 21526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T45451 WP_014483710.1 NZ_CP006715:1286213-1286506 [Bifidobacterium breve 689b]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T45451 NZ_CP006715:1286213-1286506 [Bifidobacterium breve 689b]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT45451 WP_014483711.1 NZ_CP006715:1285940-1286209 [Bifidobacterium breve 689b]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT45451 NZ_CP006715:1285940-1286209 [Bifidobacterium breve 689b]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References