Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1096327..1096963 Replicon chromosome
Accession NZ_CP006715
Organism Bifidobacterium breve 689b

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag B689B_RS04585 Protein ID WP_014484977.1
Coordinates 1096327..1096683 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6PAX1
Locus tag B689B_RS04590 Protein ID WP_012577921.1
Coordinates 1096670..1096963 (-) Length 98 a.a.

Genomic Context

B689B_RS04555B689B_RS04560B689B_RS04575B689B_RS04580B689B_RS04595B689B_RS04600B689B_RS04605B689B_RS04610B689B_RS04565B689B_RS04570B689B_RS04585B689B_RS04590
Location: 1091519..1092427 (909 bp)
Type: Others
Protein ID: WP_025332235.1
Location: 1092624..1093250 (627 bp)
Type: Others
Protein ID: WP_003829226.1
Location: 1095087..1095443 (357 bp)
Type: Others
Protein ID: WP_025332237.1
Location: 1095548..1096150 (603 bp)
Type: Others
Protein ID: WP_003829233.1
Location: 1097397..1098071 (675 bp)
Type: Others
Protein ID: WP_015438748.1
Location: 1098154..1098558 (405 bp)
Type: Others
Protein ID: WP_003829238.1
Location: 1098558..1098794 (237 bp)
Type: Others
Protein ID: WP_003829239.1
Location: 1098890..1101568 (2679 bp)
Type: Others
Protein ID: WP_003829240.1
Location: 1093587..1094369 (783 bp)
Type: Others
Protein ID: WP_015438747.1
Location: 1094512..1094997 (486 bp)
Type: Others
Protein ID: WP_025332236.1
Location: 1096327..1096683 (357 bp)
Type: Toxin
Protein ID: WP_014484977.1
Location: 1096670..1096963 (294 bp)
Type: Antitoxin
Protein ID: WP_012577921.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B689B_RS045551091519..1092427+909WP_025332235.1ABC transporter ATP-binding protein-
B689B_RS045601092624..1093250+627WP_003829226.130S ribosomal protein S4-
B689B_RS045651093587..1094369-783WP_015438747.1gamma-glutamyl-gamma-aminobutyrate hydrolase family protein-
B689B_RS045701094512..1094997-486WP_025332236.1cytidine deaminase-
B689B_RS045751095087..1095443+357WP_025332237.1SdpI family protein-
B689B_RS045801095548..1096150+603WP_003829233.1transglutaminase family protein-
B689B_RS045851096327..1096683-357WP_014484977.1type II toxin-antitoxin system PemK/MazF family toxinToxin
B689B_RS045901096670..1096963-294WP_012577921.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
B689B_RS045951097397..1098071+675WP_015438748.1histidine phosphatase family protein-
B689B_RS046001098154..1098558+405WP_003829238.1DUF948 domain-containing protein-
B689B_RS046051098558..1098794+237WP_003829239.1hypothetical protein-
B689B_RS046101098890..1101568+2679WP_003829240.1alanine--tRNA ligase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T45450 WP_014484977.1 NZ_CP006715:c1096683-1096327 [Bifidobacterium breve 689b]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

>T45450 NZ_CP006715:c1096683-1096327 [Bifidobacterium breve 689b]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10866.31 Da        Isoelectric Point: 4.2896

>AT45450 WP_012577921.1 NZ_CP006715:c1096963-1096670 [Bifidobacterium breve 689b]
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp

>AT45450 NZ_CP006715:c1096963-1096670 [Bifidobacterium breve 689b]
ATGGCTATCAAGGAGAAGACCACGATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0L7D489

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1S2VTZ6

References