Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1231620..1232186 Replicon chromosome
Accession NZ_CP006714
Organism Bifidobacterium breve NCFB 2258

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7AXF3
Locus tag B2258_RS05180 Protein ID WP_025262990.1
Coordinates 1231893..1232186 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7AY16
Locus tag B2258_RS05175 Protein ID WP_025262989.1
Coordinates 1231620..1231889 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2258_RS05150 1227369..1228064 - 696 WP_003829410.1 response regulator transcription factor -
B2258_RS05155 1228190..1228705 + 516 WP_013140733.1 hypothetical protein -
B2258_RS05160 1228702..1229592 + 891 WP_025262987.1 hypothetical protein -
B2258_RS05165 1229589..1230269 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
B2258_RS05170 1230266..1231435 + 1170 WP_025262988.1 ABC transporter permease -
B2258_RS05175 1231620..1231889 + 270 WP_025262989.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B2258_RS05180 1231893..1232186 + 294 WP_025262990.1 type II toxin-antitoxin system YafQ family toxin Toxin
B2258_RS10615 1232192..1232491 - 300 WP_025262991.1 hypothetical protein -
B2258_RS05190 1232854..1233404 + 551 Protein_1018 RNA polymerase sigma factor -
B2258_RS05195 1233438..1234265 + 828 WP_015438835.1 hypothetical protein -
B2258_RS05200 1234397..1235023 + 627 WP_025262993.1 hypothetical protein -
B2258_RS05205 1235020..1235802 + 783 WP_025262994.1 hypothetical protein -
B2258_RS05210 1235855..1236730 + 876 WP_021649674.1 ABC transporter ATP-binding protein -
B2258_RS05215 1236785..1237183 + 399 WP_015438839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1225525..1251041 25516


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11190.93 Da        Isoelectric Point: 9.7881

>T45449 WP_025262990.1 NZ_CP006714:1231893-1232186 [Bifidobacterium breve NCFB 2258]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T45449 NZ_CP006714:1231893-1232186 [Bifidobacterium breve NCFB 2258]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGAGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.12 Da        Isoelectric Point: 4.5742

>AT45449 WP_025262989.1 NZ_CP006714:1231620-1231889 [Bifidobacterium breve NCFB 2258]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT45449 NZ_CP006714:1231620-1231889 [Bifidobacterium breve NCFB 2258]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7AXF3

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7AY16

References