Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1110780..1111346 Replicon chromosome
Accession NZ_CP006712
Organism Bifidobacterium breve JCM 7017

Toxin (Protein)


Gene name relE Uniprot ID D4BPQ4
Locus tag B7017_RS04625 Protein ID WP_003829417.1
Coordinates 1110780..1111073 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag B7017_RS04630 Protein ID WP_014483711.1
Coordinates 1111077..1111346 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7017_RS04590 1105782..1106180 - 399 WP_015438839.1 hypothetical protein -
B7017_RS04595 1106235..1107110 - 876 WP_025301215.1 ABC transporter ATP-binding protein -
B7017_RS04600 1107162..1107944 - 783 WP_015438837.1 hypothetical protein -
B7017_RS04605 1107941..1108567 - 627 WP_003829423.1 hypothetical protein -
B7017_RS04610 1108700..1109527 - 828 WP_025301216.1 hypothetical protein -
B7017_RS04615 1109561..1110112 - 552 WP_025301217.1 RNA polymerase sigma factor -
B7017_RS10365 1110475..1110774 + 300 WP_003829418.1 hypothetical protein -
B7017_RS04625 1110780..1111073 - 294 WP_003829417.1 type II toxin-antitoxin system YafQ family toxin Toxin
B7017_RS04630 1111077..1111346 - 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B7017_RS04635 1111531..1112700 - 1170 WP_025301218.1 ABC transporter permease -
B7017_RS04640 1112697..1113377 - 681 WP_025301219.1 ABC transporter ATP-binding protein -
B7017_RS04645 1113374..1114264 - 891 WP_025301220.1 hypothetical protein -
B7017_RS04650 1114261..1114776 - 516 WP_038426773.1 hypothetical protein -
B7017_RS04655 1114902..1115597 + 696 WP_003829410.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1092286..1133481 41195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.92 Da        Isoelectric Point: 9.8306

>T45443 WP_003829417.1 NZ_CP006712:c1111073-1110780 [Bifidobacterium breve JCM 7017]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

>T45443 NZ_CP006712:c1111073-1110780 [Bifidobacterium breve JCM 7017]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT45443 WP_014483711.1 NZ_CP006712:c1111346-1111077 [Bifidobacterium breve JCM 7017]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT45443 NZ_CP006712:c1111346-1111077 [Bifidobacterium breve JCM 7017]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7C7H2

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References