Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1014688..1015324 Replicon chromosome
Accession NZ_CP006711
Organism Bifidobacterium breve 12L

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag B12L_RS04170 Protein ID WP_025299776.1
Coordinates 1014688..1015044 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag B12L_RS04175 Protein ID WP_025299777.1
Coordinates 1015031..1015324 (-) Length 98 a.a.

Genomic Context

B12L_RS04140B12L_RS04145B12L_RS04160B12L_RS04165B12L_RS04180B12L_RS04185B12L_RS04190B12L_RS04195B12L_RS04200B12L_RS04150B12L_RS04155B12L_RS04170B12L_RS04175
Location: 1009741..1010652 (912 bp)
Type: Others
Protein ID: WP_025299772.1
Location: 1010849..1011475 (627 bp)
Type: Others
Protein ID: WP_003829226.1
Location: 1013448..1013804 (357 bp)
Type: Others
Protein ID: WP_025299775.1
Location: 1013909..1014511 (603 bp)
Type: Others
Protein ID: WP_003829233.1
Location: 1015576..1016250 (675 bp)
Type: Others
Protein ID: WP_015438748.1
Location: 1016333..1016716 (384 bp)
Type: Others
Protein ID: WP_016463075.1
Location: 1016716..1016952 (237 bp)
Type: Others
Protein ID: WP_003829239.1
Location: 1017048..1019726 (2679 bp)
Type: Others
Protein ID: WP_025299778.1
Location: 1019735..1020187 (453 bp)
Type: Others
Protein ID: WP_003829241.1
Location: 1011950..1012732 (783 bp)
Type: Others
Protein ID: WP_025299773.1
Location: 1012870..1013355 (486 bp)
Type: Others
Protein ID: WP_025299774.1
Location: 1014688..1015044 (357 bp)
Type: Toxin
Protein ID: WP_025299776.1
Location: 1015031..1015324 (294 bp)
Type: Antitoxin
Protein ID: WP_025299777.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B12L_RS041401009741..1010652+912WP_025299772.1ABC transporter ATP-binding protein-
B12L_RS041451010849..1011475+627WP_003829226.130S ribosomal protein S4-
B12L_RS041501011950..1012732-783WP_025299773.1gamma-glutamyl-gamma-aminobutyrate hydrolase family protein-
B12L_RS041551012870..1013355-486WP_025299774.1cytidine deaminase-
B12L_RS041601013448..1013804+357WP_025299775.1SdpI family protein-
B12L_RS041651013909..1014511+603WP_003829233.1transglutaminase family protein-
B12L_RS041701014688..1015044-357WP_025299776.1type II toxin-antitoxin system PemK/MazF family toxinToxin
B12L_RS041751015031..1015324-294WP_025299777.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
B12L_RS041801015576..1016250+675WP_015438748.1histidine phosphatase family protein-
B12L_RS041851016333..1016716+384WP_016463075.1DUF948 domain-containing protein-
B12L_RS041901016716..1016952+237WP_003829239.1hypothetical protein-
B12L_RS041951017048..1019726+2679WP_025299778.1alanine--tRNA ligase-
B12L_RS042001019735..1020187+453WP_003829241.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13292.21 Da        Isoelectric Point: 8.9603

>T45440 WP_025299776.1 NZ_CP006711:c1015044-1014688 [Bifidobacterium breve 12L]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYSGLLA

Download         Length: 357 bp

>T45440 NZ_CP006711:c1015044-1014688 [Bifidobacterium breve 12L]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATTCGGGCCTACTAGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10864.33 Da        Isoelectric Point: 4.2896

>AT45440 WP_025299777.1 NZ_CP006711:c1015324-1015031 [Bifidobacterium breve 12L]
MAIKEKATISLDAQTKRDGIAILDAMGLNLSTFVEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp

>AT45440 NZ_CP006711:c1015324-1015031 [Bifidobacterium breve 12L]
ATGGCTATCAAGGAGAAGGCCACGATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGTCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References