Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 954436..954991 Replicon chromosome
Accession NZ_CP006711
Organism Bifidobacterium breve 12L

Toxin (Protein)


Gene name mazF Uniprot ID S2ZXD7
Locus tag B12L_RS03890 Protein ID WP_003829109.1
Coordinates 954436..954759 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S2ZDC4
Locus tag B12L_RS03895 Protein ID WP_003829112.1
Coordinates 954746..954991 (-) Length 82 a.a.

Genomic Context

B12L_RS03880B12L_RS09755B12L_RS03900B12L_RS03905B12L_RS10375B12L_RS09745B12L_RS03870B12L_RS03875B12L_RS03890B12L_RS03895B12L_RS03910B12L_RS03915
Location: 952642..953511 (870 bp)
Type: Others
Protein ID: WP_003829104.1
Location: 953605..954219 (615 bp)
Type: Others
Protein ID: WP_003829107.1
Location: 955163..956419 (1257 bp)
Type: Others
Protein ID: WP_019728042.1
Location: 956684..956875 (192 bp)
Type: Others
Protein ID: WP_003829118.1
Location: 959612..959797 (186 bp)
Type: Others
Protein ID: WP_003808830.1
Location: 949468..949756 (289 bp)
Type: Others
Protein ID: Protein_759
Location: 950232..951497 (1266 bp)
Type: Others
Protein ID: WP_025299743.1
Location: 952039..952404 (366 bp)
Type: Others
Protein ID: WP_025299744.1
Location: 954436..954759 (324 bp)
Type: Toxin
Protein ID: WP_003829109.1
Location: 954746..954991 (246 bp)
Type: Antitoxin
Protein ID: WP_003829112.1
Location: 957059..958330 (1272 bp)
Type: Others
Protein ID: WP_003829121.1
Location: 958487..959149 (663 bp)
Type: Others
Protein ID: WP_019728044.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B12L_RS09745949468..949756-289Protein_759IS256 family transposase-
B12L_RS03870950232..951497-1266WP_025299743.1Fic family protein-
B12L_RS03875952039..952404-366WP_025299744.1YccF domain-containing protein-
B12L_RS03880952642..953511+870WP_003829104.1class I SAM-dependent methyltransferase-
B12L_RS09755953605..954219+615WP_003829107.1cupin domain-containing protein-
B12L_RS03890954436..954759-324WP_003829109.1type II toxin-antitoxin system PemK/MazF family toxinToxin
B12L_RS03895954746..954991-246WP_003829112.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
B12L_RS03900955163..956419+1257WP_019728042.1HipA domain-containing protein-
B12L_RS03905956684..956875+192WP_003829118.1hypothetical protein-
B12L_RS03910957059..958330-1272WP_003829121.1MFS transporter-
B12L_RS03915958487..959149-663WP_019728044.1TetR/AcrR family transcriptional regulator-
B12L_RS10375959612..959797+186WP_003808830.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--945117..97960034483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11859.67 Da        Isoelectric Point: 5.0771

>T45439 WP_003829109.1 NZ_CP006711:c954759-954436 [Bifidobacterium breve 12L]
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T45439 NZ_CP006711:c954759-954436 [Bifidobacterium breve 12L]
ATGAAACGAGGTGAGATTTGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGAT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9339.43 Da        Isoelectric Point: 4.5881

>AT45439 WP_003829112.1 NZ_CP006711:c954991-954746 [Bifidobacterium breve 12L]
MSMQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp

>AT45439 NZ_CP006711:c954991-954746 [Bifidobacterium breve 12L]
ATGAGCATGCAGATTGCCACGCGAGTTGATGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGTACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A087B6Q7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A087B6Q6

References