Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5814088..5815778 Replicon chromosome
Accession NZ_CP006704
Organism Comamonas testosteroni TK102

Toxin (Protein)


Gene name doc Uniprot ID A0A076Q091
Locus tag O987_RS26385 Protein ID WP_043375747.1
Coordinates 5814900..5815778 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A076PRU1
Locus tag O987_RS26380 Protein ID WP_043375746.1
Coordinates 5814088..5814894 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O987_RS26360 5810098..5810874 - 777 WP_003060420.1 SDR family oxidoreductase -
O987_RS26365 5811189..5811947 - 759 WP_019044150.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
O987_RS26370 5812068..5813054 - 987 WP_043375744.1 tripartite tricarboxylate transporter substrate binding protein -
O987_RS26375 5813245..5814045 - 801 WP_003060414.1 aspartate dehydrogenase -
O987_RS26380 5814088..5814894 - 807 WP_043375746.1 IclR family transcriptional regulator Antitoxin
O987_RS26385 5814900..5815778 - 879 WP_043375747.1 alpha/beta hydrolase Toxin
O987_RS26390 5815787..5816320 - 534 WP_003060408.1 cupin domain-containing protein -
O987_RS26395 5816557..5818233 - 1677 WP_043375749.1 long-chain-fatty-acid--CoA ligase -
O987_RS26400 5818447..5819511 - 1065 WP_003060402.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30429.89 Da        Isoelectric Point: 6.6025

>T45438 WP_043375747.1 NZ_CP006704:c5815778-5814900 [Comamonas testosteroni TK102]
MHEDLLSPKLQLLQTGFPERLVKLPQNAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLGDKARVLAWDAPGYGV
STPLAPAAPADADYAQALAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVFISPAGGYGAAAKAEQQAKVRA
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVQVWVGEHDVV
TPPAACKAWSELLGAHYGTLAAAGHASPVEQPVEVAHRLASLLNQSYLPNTS

Download         Length: 879 bp

>T45438 NZ_CP006704:c5815778-5814900 [Comamonas testosteroni TK102]
ATGCACGAGGATTTGCTGTCGCCGAAGCTGCAGCTGCTGCAGACCGGATTTCCCGAGCGACTGGTAAAGCTCCCGCAGAA
CGCTCAGGTTGCCTGGCGCGAGGCGGGCGATGCCAGCTCCGATTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCCTCCTGGCTGGATGTGGCGCTGCAGCTGGGTGACAAGGCGCGCGTTCTGGCCTGGGATGCACCCGGCTATGGCGTG
TCGACGCCGCTGGCGCCAGCCGCGCCTGCCGATGCCGACTATGCGCAGGCGCTGGCCCAGTCACTGCTGGTGCTGGGCGT
GCGGCGCTGTCTGCTGGTCGGCCATTCCCTGGGCGCCCTGATGGCTGCCAGGCTGGCGGTCACGGCGGCCCCCGGACTGG
TCGAGCAACTGGTGTTCATCAGCCCGGCCGGCGGTTACGGCGCAGCGGCCAAGGCCGAGCAGCAAGCCAAGGTGCGCGCA
GGACGTCTGGCTGCGCTGGCCGAGAAAGGTGTCGCCGGCCTGGCGGCCGTCATCGACCAGCGTCTGGTGTCTTCCGAAGC
CCCTGAAGCCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TCTGCGGCAGTGATCTGGCGCAGGCACAGGGCAGGCTGGGCATGCCGGTTCAGGTCTGGGTCGGCGAGCACGATGTGGTG
ACTCCGCCTGCAGCTTGCAAAGCCTGGTCCGAGTTGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCTGTGGAGGTTGCGCATAGGCTGGCATCTTTGTTGAACCAAAGTTATTTGCCCAACACCAGCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29265.23 Da        Isoelectric Point: 4.8865

>AT45438 WP_043375746.1 NZ_CP006704:c5814894-5814088 [Comamonas testosteroni TK102]
MSETPEISTNDQDRYTVPALERGLRLLACFGPEQPVWSAPELARNLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPALQALCDELGMTSNLALRDGASVVYVARVTPAGAFQGAVRVGSRLPAHATVLGRALLHDMDA
AQLRSVFGGEELPQFSESTPRNIDELLDLLAQDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELVPEK
TQLWVQKVQEAAEALSAHLRQQHPDHLR

Download         Length: 807 bp

>AT45438 NZ_CP006704:c5814894-5814088 [Comamonas testosteroni TK102]
ATGAGCGAAACCCCAGAGATTTCAACCAACGACCAAGACCGTTACACCGTGCCCGCCCTCGAGCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGAGCAACCTGTCTGGAGCGCGCCCGAGCTGGCGCGCAACCTCGAGCTGCCGCGTTCCACGGTGT
TTCGGATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGTACCGAATACCGACTCGGTCTGGCCGTGCTG
CGTCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGCTCTGCAGGCCTTGTGTGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGTGACGGCGCCTCCGTGGTCTATGTGGCACGCGTCACTCCGGCCGGAGCGTTCC
AGGGCGCTGTGCGCGTGGGCTCGCGCTTGCCTGCACATGCGACGGTGCTGGGGCGAGCCCTGCTGCATGACATGGATGCC
GCGCAACTGCGCTCGGTGTTTGGCGGCGAGGAATTGCCCCAGTTCTCCGAGAGCACGCCGCGCAACATCGACGAGCTGCT
GGACCTGCTGGCCCAGGACCGTGAGCGTGGCTACGCCATGGGCGAGGGCTTTTACGAGCCAGGTGTTTCCAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCGGGTGGTTGCGGGACTGGCCATGGCCATTCCGTTTACCGAGCTGGTGCCCGAGAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAAGAGGCGGCAGAAGCCCTGTCCGCTCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076Q091

Antitoxin

Source ID Structure
AlphaFold DB A0A076PRU1

References