Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 2750..3336 | Replicon | plasmid unnamed1 |
Accession | NZ_CP006697 | ||
Organism | Xylella fastidiosa subsp. sandyi Ann-1 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A060HFH6 |
Locus tag | D934_RS12725 | Protein ID | WP_024748613.1 |
Coordinates | 2750..3076 (-) | Length | 109 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | D5LL99 |
Locus tag | D934_RS12730 | Protein ID | WP_013087943.1 |
Coordinates | 3073..3336 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D934_RS12710 | 74..1180 | + | 1107 | WP_020852265.1 | hypothetical protein | - |
D934_RS12715 | 1228..1515 | + | 288 | WP_020852266.1 | DUF4190 domain-containing protein | - |
D934_RS12720 | 1687..2691 | + | 1005 | WP_020852267.1 | relaxase/mobilization nuclease domain-containing protein | - |
D934_RS12725 | 2750..3076 | - | 327 | WP_024748613.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
D934_RS12730 | 3073..3336 | - | 264 | WP_013087943.1 | antitoxin | Antitoxin |
D934_RS12735 | 3448..4656 | + | 1209 | WP_042836803.1 | transposase | - |
D934_RS12740 | 4936..5199 | + | 264 | WP_080702547.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
D934_RS12745 | 5171..5500 | + | 330 | WP_024748578.1 | type II toxin-antitoxin system YafQ family toxin | - |
D934_RS12750 | 5631..6074 | - | 444 | WP_014607318.1 | hypothetical protein | - |
D934_RS12755 | 6075..6827 | - | 753 | WP_020852243.1 | hypothetical protein | - |
D934_RS12760 | 6840..7196 | - | 357 | WP_020852242.1 | hypothetical protein | - |
D934_RS12765 | 7540..8103 | + | 564 | WP_038273547.1 | plasmid mobilization relaxosome protein MobC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..30305 | 30305 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 11795.71 Da Isoelectric Point: 8.5480
>T45435 WP_024748613.1 NZ_CP006697:c3076-2750 [Xylella fastidiosa subsp. sandyi Ann-1]
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
IARNARKVESLPPNILADVLAKAVTIFQ
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
IARNARKVESLPPNILADVLAKAVTIFQ
Download Length: 327 bp
>T45435 NZ_CP006697:c3076-2750 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGAAACGCGGCGATGTTTACATGGTCGATCTGGAGCCAACCGCCGGGCACGAACAACGCGGTCACCGTCCGGTGGTTGT
TATCTCCAGTGAGCGATTCAATCGGCTTACCTCTTGTCCGGTGATCCTTCCAATCACAAACGGCGGCGAGTTCGCCTCCC
GCCTCGGGTTCGCTGTGGAATTACTAGGTACGATTACAACGGGCGTCGTTCGATGTGATCAACCACGTGCACTCGACTTA
ATCGCTCGCAATGCCCGCAAAGTGGAAAGCCTACCACCAAACATCTTGGCCGATGTCTTGGCAAAAGCTGTCACCATCTT
CCAGTAA
ATGAAACGCGGCGATGTTTACATGGTCGATCTGGAGCCAACCGCCGGGCACGAACAACGCGGTCACCGTCCGGTGGTTGT
TATCTCCAGTGAGCGATTCAATCGGCTTACCTCTTGTCCGGTGATCCTTCCAATCACAAACGGCGGCGAGTTCGCCTCCC
GCCTCGGGTTCGCTGTGGAATTACTAGGTACGATTACAACGGGCGTCGTTCGATGTGATCAACCACGTGCACTCGACTTA
ATCGCTCGCAATGCCCGCAAAGTGGAAAGCCTACCACCAAACATCTTGGCCGATGTCTTGGCAAAAGCTGTCACCATCTT
CCAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9365.77 Da Isoelectric Point: 4.3588
>AT45435 WP_013087943.1 NZ_CP006697:c3336-3073 [Xylella fastidiosa subsp. sandyi Ann-1]
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI
Download Length: 264 bp
>AT45435 NZ_CP006697:c3336-3073 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGCACACCACAAACCTTCGTAAAGTCGGCGGATCGATCATGCTGGCCGTTCCCCCCGCTTTCCTTGACCAGCTTCATCT
TGAGGTCGGCGCAACGGTCGGCTTAGCCGTCACAGACGGTCGTCTGGTCATTGAGCCAGTCCTACATCCTCAGTACACGC
TGGATCAACTGCTGGCCGAAGCGGAAGCCTCCGGGGCTTACCCGTTGCCGCCCGAGGAACGTGAATGGGTCGATGCTCCA
GCAGTAGGACGCGAACTGATATGA
ATGCACACCACAAACCTTCGTAAAGTCGGCGGATCGATCATGCTGGCCGTTCCCCCCGCTTTCCTTGACCAGCTTCATCT
TGAGGTCGGCGCAACGGTCGGCTTAGCCGTCACAGACGGTCGTCTGGTCATTGAGCCAGTCCTACATCCTCAGTACACGC
TGGATCAACTGCTGGCCGAAGCGGAAGCCTCCGGGGCTTACCCGTTGCCGCCCGAGGAACGTGAATGGGTCGATGCTCCA
GCAGTAGGACGCGAACTGATATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HFH6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060H856 |