Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2456321..2456932 Replicon chromosome
Accession NZ_CP006696
Organism Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag D934_RS11525 Protein ID WP_024749166.1
Coordinates 2456321..2456620 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag D934_RS11530 Protein ID WP_004085003.1
Coordinates 2456624..2456932 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D934_RS11475 2451478..2451774 + 297 WP_004089252.1 type II toxin-antitoxin system RelE/ParE family toxin -
D934_RS11480 2451778..2452083 + 306 WP_004089254.1 putative addiction module antidote protein -
D934_RS11485 2452094..2452447 - 354 WP_020851652.1 hypothetical protein -
D934_RS11490 2452444..2453085 - 642 WP_020851653.1 phage-related protein -
D934_RS11495 2453082..2453912 - 831 WP_042836628.1 hypothetical protein -
D934_RS11500 2453909..2454226 - 318 WP_020851655.1 hypothetical protein -
D934_RS11505 2454226..2454996 - 771 WP_024749165.1 hypothetical protein -
D934_RS11510 2455054..2455380 + 327 WP_004091353.1 type II toxin-antitoxin system RelE/ParE family toxin -
D934_RS11515 2455377..2455658 + 282 WP_004091355.1 helix-turn-helix domain-containing protein -
D934_RS14555 2455717..2456010 - 294 Protein_2272 hypothetical protein -
D934_RS11520 2456012..2456233 - 222 Protein_2273 hypothetical protein -
D934_RS11525 2456321..2456620 + 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D934_RS11530 2456624..2456932 + 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
D934_RS11535 2457006..2458895 - 1890 WP_042836631.1 hypothetical protein -
D934_RS11540 2459043..2459465 - 423 WP_020852390.1 hypothetical protein -
D934_RS11545 2459462..2459899 - 438 WP_004087249.1 DUF3277 family protein -
D934_RS14090 2459909..2460133 - 225 Protein_2279 DUF3383 family protein -
D934_RS11550 2460362..2461556 - 1195 Protein_2280 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2428131..2468690 40559
- flank IS/Tn - - 2461550..2461771 221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T45434 WP_024749166.1 NZ_CP006696:2456321-2456620 [Xylella fastidiosa subsp. sandyi Ann-1]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T45434 NZ_CP006696:2456321-2456620 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT45434 WP_004085003.1 NZ_CP006696:2456624-2456932 [Xylella fastidiosa subsp. sandyi Ann-1]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT45434 NZ_CP006696:2456624-2456932 [Xylella fastidiosa subsp. sandyi Ann-1]
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References