Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 2456321..2456932 | Replicon | chromosome |
Accession | NZ_CP006696 | ||
Organism | Xylella fastidiosa subsp. sandyi Ann-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A060HHU8 |
Locus tag | D934_RS11525 | Protein ID | WP_024749166.1 |
Coordinates | 2456321..2456620 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q879U0 |
Locus tag | D934_RS11530 | Protein ID | WP_004085003.1 |
Coordinates | 2456624..2456932 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D934_RS11475 | 2451478..2451774 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
D934_RS11480 | 2451778..2452083 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | - |
D934_RS11485 | 2452094..2452447 | - | 354 | WP_020851652.1 | hypothetical protein | - |
D934_RS11490 | 2452444..2453085 | - | 642 | WP_020851653.1 | phage-related protein | - |
D934_RS11495 | 2453082..2453912 | - | 831 | WP_042836628.1 | hypothetical protein | - |
D934_RS11500 | 2453909..2454226 | - | 318 | WP_020851655.1 | hypothetical protein | - |
D934_RS11505 | 2454226..2454996 | - | 771 | WP_024749165.1 | hypothetical protein | - |
D934_RS11510 | 2455054..2455380 | + | 327 | WP_004091353.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
D934_RS11515 | 2455377..2455658 | + | 282 | WP_004091355.1 | helix-turn-helix domain-containing protein | - |
D934_RS14555 | 2455717..2456010 | - | 294 | Protein_2272 | hypothetical protein | - |
D934_RS11520 | 2456012..2456233 | - | 222 | Protein_2273 | hypothetical protein | - |
D934_RS11525 | 2456321..2456620 | + | 300 | WP_024749166.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
D934_RS11530 | 2456624..2456932 | + | 309 | WP_004085003.1 | putative addiction module antidote protein | Antitoxin |
D934_RS11535 | 2457006..2458895 | - | 1890 | WP_042836631.1 | hypothetical protein | - |
D934_RS11540 | 2459043..2459465 | - | 423 | WP_020852390.1 | hypothetical protein | - |
D934_RS11545 | 2459462..2459899 | - | 438 | WP_004087249.1 | DUF3277 family protein | - |
D934_RS14090 | 2459909..2460133 | - | 225 | Protein_2279 | DUF3383 family protein | - |
D934_RS11550 | 2460362..2461556 | - | 1195 | Protein_2280 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2428131..2468690 | 40559 | |
- | flank | IS/Tn | - | - | 2461550..2461771 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11364.14 Da Isoelectric Point: 10.3861
>T45434 WP_024749166.1 NZ_CP006696:2456321-2456620 [Xylella fastidiosa subsp. sandyi Ann-1]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED
Download Length: 300 bp
>T45434 NZ_CP006696:2456321-2456620 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11060.61 Da Isoelectric Point: 4.6535
>AT45434 WP_004085003.1 NZ_CP006696:2456624-2456932 [Xylella fastidiosa subsp. sandyi Ann-1]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH
Download Length: 309 bp
>AT45434 NZ_CP006696:2456624-2456932 [Xylella fastidiosa subsp. sandyi Ann-1]
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HHU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HCD4 |