Detailed information of TA system TA045432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2160482..2161044
• Replicon: chromosome
• Accession: NZ_CP006696
• Organism: Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A060H8A8
• Locus tag: D934_RS10110
• Protein ID: WP_024748859.1
• Coordinates: 2160748..2161044 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A060H455
• Locus tag: D934_RS10105
• Protein ID: WP_020852177.1
• Coordinates: 2160482..2160760 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D934_RS13935	2155494..2155714	+	221	Protein_1973	DUF4158 domain-containing protein	-
D934_RS10075	2155922..2156242	-	321	WP_024748857.1	hypothetical protein	-
D934_RS10080	2156310..2156905	-	596	Protein_1975	hypothetical protein	-
D934_RS13940	2158626..2158781	-	156	Protein_1976	YkgJ family cysteine cluster protein	-
D934_RS10090	2158852..2159409	-	558	WP_020852174.1	recombinase family protein	-
D934_RS14825	2159427..2159594	-	168	WP_196230068.1	hypothetical protein	-
D934_RS10095	2159599..2159973	-	375	WP_020852175.1	DUF5615 family PIN-like protein	-
D934_RS10100	2159970..2160200	-	231	WP_004091411.1	DUF433 domain-containing protein	-
D934_RS10105	2160482..2160760	+	279	WP_020852177.1	CopG family ribbon-helix-helix protein	Antitoxin
D934_RS10110	2160748..2161044	+	297	WP_024748859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D934_RS13945	2161115..2161336	+	222	WP_155244236.1	hypothetical protein	-
D934_RS10115	2161272..2161706	+	435	WP_020852179.1	baseplate J/gp47 family protein	-
D934_RS10120	2161708..2162368	+	661	Protein_1985	hypothetical protein	-
D934_RS10125	2162295..2162746	+	452	Protein_1986	hypothetical protein	-
D934_RS14530	2162803..2162940	+	138	WP_155244237.1	hypothetical protein	-
D934_RS14535	2163048..2163308	+	261	WP_024748860.1	hypothetical protein	-
D934_RS10135	2163839..2164078	-	240	WP_024748861.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11243.98 Da
• Isoelectric Point: 10.4229

>T45432 WP_024748859.1 NZ_CP006696:2160748-2161044 [Xylella fastidiosa subsp. sandyi Ann-1]
MPRVIFVPEAIRNIQRLRKFLHPKNGDAAKRAGEIVMRGTRMLGAQPRIGRPVDALPDEYREWLIDFGDSGYVAHYRIDG
DTVTILAVRHQKEVGYTR

Nucleotide

• Length: 297 bp

>T45432 NZ_CP006696:2160748-2161044 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGCCACGGGTGATCTTCGTTCCCGAAGCCATCCGGAACATTCAACGATTGCGGAAATTCCTGCATCCGAAGAACGGCGA
TGCCGCAAAGCGGGCCGGTGAAATCGTCATGCGGGGTACGCGGATGCTCGGAGCGCAGCCACGTATCGGCCGACCGGTTG
ATGCCCTGCCCGATGAGTACCGGGAATGGCTAATTGACTTCGGAGATAGCGGTTATGTGGCCCACTACCGCATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCAGAAGGAAGTGGGATACACCAGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10737.08 Da
• Isoelectric Point: 5.6126

>AT45432 WP_020852177.1 NZ_CP006696:2160482-2160760 [Xylella fastidiosa subsp. sandyi Ann-1]
MGMATSIKLDDELKGRVQHLADVRRRTAHWIMREAIAQYVEREEKREAFRQDTLKAWEEFQATGLHVTAEEVEKWLSSWG
TENELQAPVCHG

Nucleotide

• Length: 279 bp

>AT45432 NZ_CP006696:2160482-2160760 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TGCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAAGAAAAGCGTGAGGCGTTCCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGGCCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGCAAGCGCCCGTATGCCACGGGTGA

Structures

Toxin

• AlphaFold DB: A0A060H8A8

Antitoxin

• AlphaFold DB: A0A060H455