Detailed information of TA system TA045426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 1377655..1378328
• Replicon: chromosome
• Accession: NZ_CP006696
• Organism: Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D934_RS06265
• Protein ID: WP_024748528.1
• Coordinates: 1377655..1378059 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D934_RS06270
• Protein ID: WP_024748527.1
• Coordinates: 1378056..1378328 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D934_RS06240	1372711..1373244	+	534	WP_020852388.1	hypothetical protein	-
D934_RS06245	1373245..1374741	+	1497	WP_020852389.1	DUF3383 domain-containing protein	-
D934_RS06250	1374751..1375188	+	438	WP_004087249.1	DUF3277 family protein	-
D934_RS06255	1375185..1375607	+	423	WP_020851660.1	hypothetical protein	-
D934_RS06260	1375755..1377644	+	1890	WP_020851659.1	phage-related protein	-
D934_RS06265	1377655..1378059	-	405	WP_024748528.1	type II toxin-antitoxin system VapC family toxin	Toxin
D934_RS06270	1378056..1378328	-	273	WP_024748527.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D934_RS06275	1378488..1379258	+	771	WP_020851656.1	hypothetical protein	-
D934_RS06280	1379258..1379575	+	318	WP_020851655.1	hypothetical protein	-
D934_RS06285	1379572..1380402	+	831	WP_020851654.1	hypothetical protein	-
D934_RS06290	1380399..1381040	+	642	WP_020851653.1	phage-related protein	-
D934_RS06295	1381037..1381390	+	354	WP_020851652.1	hypothetical protein	-
D934_RS06300	1381401..1381706	-	306	WP_004089254.1	putative addiction module antidote protein	-
D934_RS06305	1381710..1382006	-	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D934_RS06310	1382105..1383250	+	1146	WP_020851651.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1292345..1385055	92710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14653.95 Da
• Isoelectric Point: 5.6881

>T45426 WP_024748528.1 NZ_CP006696:c1378059-1377655 [Xylella fastidiosa subsp. sandyi Ann-1]
VSGYMLDTNIISDIIRNPFGAVACRIEHVGYPNICTSVIVAAELRYGCTKNGSVKLLSRVQDILKTLPILPLDIPVDTTY
GSIRAELEAAGQLIGANDLLIAAHAYVLGLTLVTDNTREFSRIRGLDVQNWLER

Nucleotide

• Length: 405 bp

>T45426 NZ_CP006696:c1378059-1377655 [Xylella fastidiosa subsp. sandyi Ann-1]
GTGAGCGGCTATATGCTCGACACAAATATCATCAGCGATATCATTCGTAACCCATTCGGGGCGGTGGCTTGCCGTATTGA
ACACGTTGGGTATCCGAACATTTGCACGAGCGTTATCGTGGCGGCCGAACTTCGCTATGGATGCACGAAAAATGGCTCGG
TAAAGCTGCTGAGCAGGGTACAGGACATTCTTAAAACGCTGCCGATCCTGCCTTTGGACATACCTGTTGACACAACATAT
GGCAGTATCCGTGCTGAGCTGGAGGCTGCGGGTCAGCTGATCGGCGCTAATGATCTATTGATTGCTGCGCATGCTTACGT
ACTCGGGCTGACTTTGGTCACGGACAACACCCGCGAGTTCAGCCGAATTCGCGGCTTGGATGTGCAAAACTGGCTAGAGA
GGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10396.87 Da
• Isoelectric Point: 4.8782

>AT45426 WP_024748527.1 NZ_CP006696:c1378328-1378056 [Xylella fastidiosa subsp. sandyi Ann-1]
MPISSPLSRTKEAKLFRNNRSQAVRIPVEFELSGDRVLIHREGSKLIIEPITRPTNIVELLHEWRRETPLGPEDQFPDID
DMPAQPEDIL

Nucleotide

• Length: 273 bp

>AT45426 NZ_CP006696:c1378328-1378056 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGCCAATTTCATCTCCGTTATCACGTACTAAGGAAGCGAAGCTATTCCGAAATAATCGTAGCCAGGCGGTACGAATTCC
CGTTGAATTCGAGCTGTCGGGCGATCGTGTTCTGATCCACCGTGAGGGGAGCAAGCTCATTATTGAGCCGATCACCAGGC
CAACCAATATTGTTGAATTACTGCACGAGTGGCGAAGAGAAACACCACTCGGCCCAGAGGATCAATTCCCTGATATTGAT
GACATGCCCGCTCAGCCAGAGGATATTCTGTGA