Detailed information of TA system TA045424

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 662326..662857
• Replicon: chromosome
• Accession: NZ_CP006696
• Organism: Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A060GYI0
• Locus tag: D934_RS02760
• Protein ID: WP_020853121.1
• Coordinates: 662576..662857 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A060H1U9
• Locus tag: D934_RS02755
• Protein ID: WP_020853122.1
• Coordinates: 662326..662589 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D934_RS02730	657552..658730	-	1179	WP_020850953.1	phage tail sheath family protein	-
D934_RS02735	658795..660387	-	1593	WP_024748652.1	tail fiber domain-containing protein	-
D934_RS02740	660395..660952	-	558	WP_020852723.1	phage tail protein I	-
D934_RS02745	660945..661838	-	894	WP_020850956.1	baseplate J/gp47 family protein	-
D934_RS02750	661838..662176	-	339	WP_004088650.1	GPW/gp25 family protein	-
D934_RS02755	662326..662589	+	264	WP_020853122.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D934_RS02760	662576..662857	+	282	WP_020853121.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D934_RS02765	662894..663481	-	588	WP_024748577.1	phage baseplate assembly protein V	-
D934_RS02770	663478..664020	-	543	WP_020850961.1	hypothetical protein	-
D934_RS02775	663996..664517	-	522	WP_020850962.1	hypothetical protein	-
D934_RS02780	664514..664837	-	324	WP_020850963.1	hypothetical protein	-
D934_RS02785	664837..665097	-	261	WP_020850964.1	hypothetical protein	-
D934_RS02790	665115..666989	-	1875	WP_020850965.1	phage major capsid protein	-
D934_RS02795	666986..667618	-	633	WP_020850966.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	635034..671730	36696

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10892.32 Da
• Isoelectric Point: 7.2205

>T45424 WP_020853121.1 NZ_CP006696:662576-662857 [Xylella fastidiosa subsp. sandyi Ann-1]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVVEALACDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T45424 NZ_CP006696:662576-662857 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGCGGAGGATTAGTCAGACTGGCCAGTTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTAATACACGTCGTAGAAGCCTTGGCCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGGATTGGCTCACACAGCGAACTAGGCTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9422.90 Da
• Isoelectric Point: 6.7245

>AT45424 WP_020853122.1 NZ_CP006696:662326-662589 [Xylella fastidiosa subsp. sandyi Ann-1]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNATTIAAMREARAGHLKSFNSIEGLM
ADLHAED

Nucleotide

• Length: 264 bp

>AT45424 NZ_CP006696:662326-662589 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGTCTGCAAACGCAGTTGTCCGTGCTCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTACTGGCGACGATGGG
CCTAAGCGTGTCTGACGCGTTCCGTATGATGCTGACCCGCATTGCCCGCGAGAAGGCGCTGCCGTTCGAGCCGCTGGTGC
CGAACGCAACCACTATCGCAGCCATGCGCGAAGCCCGCGCTGGTCACCTCAAGAGCTTTAACAGCATTGAGGGGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Structures

Toxin

• AlphaFold DB: A0A060GYI0

Antitoxin

• AlphaFold DB: A0A060H1U9