Detailed information of TA system TA045423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 179884..180361
• Replicon: chromosome
• Accession: NZ_CP006696
• Organism: Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: Q87CA4
• Locus tag: D934_RS00730
• Protein ID: WP_011097988.1
• Coordinates: 179884..180150 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: D934_RS00735
• Protein ID: WP_004091377.1
• Coordinates: 180134..180361 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D934_RS00700	176526..177287	-	762	WP_042836340.1	Bax inhibitor-1/YccA family protein	-
D934_RS00725	178479..179873	+	1395	WP_042836341.1	hypothetical protein	-
D934_RS00730	179884..180150	-	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D934_RS00735	180134..180361	-	228	WP_004091377.1	hypothetical protein	Antitoxin
D934_RS00740	180472..181014	+	543	WP_020852392.1	hypothetical protein	-
D934_RS00745	181335..181724	-	390	WP_024749101.1	DUF596 domain-containing protein	-
D934_RS00750	181735..182034	-	300	WP_196230083.1	hemagglutinin	-
D934_RS00755	182300..182677	-	378	WP_020852395.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10163.79 Da
• Isoelectric Point: 10.6086

>T45423 WP_011097988.1 NZ_CP006696:c180150-179884 [Xylella fastidiosa subsp. sandyi Ann-1]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T45423 NZ_CP006696:c180150-179884 [Xylella fastidiosa subsp. sandyi Ann-1]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT45423 WP_004091377.1 NZ_CP006696:c180361-180134 [Xylella fastidiosa subsp. sandyi Ann-1]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT45423 NZ_CP006696:c180361-180134 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: A0A060HDH1

Antitoxin

• AlphaFold DB: A0A7G7TPD2