Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 179884..180361 Replicon chromosome
Accession NZ_CP006696
Organism Xylella fastidiosa subsp. sandyi Ann-1

Toxin (Protein)


Gene name pasB Uniprot ID Q87CA4
Locus tag D934_RS00730 Protein ID WP_011097988.1
Coordinates 179884..180150 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7G7TPD2
Locus tag D934_RS00735 Protein ID WP_004091377.1
Coordinates 180134..180361 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D934_RS00700 176526..177287 - 762 WP_042836340.1 Bax inhibitor-1/YccA family protein -
D934_RS00725 178479..179873 + 1395 WP_042836341.1 hypothetical protein -
D934_RS00730 179884..180150 - 267 WP_011097988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D934_RS00735 180134..180361 - 228 WP_004091377.1 hypothetical protein Antitoxin
D934_RS00740 180472..181014 + 543 WP_020852392.1 hypothetical protein -
D934_RS00745 181335..181724 - 390 WP_024749101.1 DUF596 domain-containing protein -
D934_RS00750 181735..182034 - 300 WP_196230083.1 hemagglutinin -
D934_RS00755 182300..182677 - 378 WP_020852395.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10163.79 Da        Isoelectric Point: 10.6086

>T45423 WP_011097988.1 NZ_CP006696:c180150-179884 [Xylella fastidiosa subsp. sandyi Ann-1]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Download         Length: 267 bp

>T45423 NZ_CP006696:c180150-179884 [Xylella fastidiosa subsp. sandyi Ann-1]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8615.63 Da        Isoelectric Point: 5.0958

>AT45423 WP_004091377.1 NZ_CP006696:c180361-180134 [Xylella fastidiosa subsp. sandyi Ann-1]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT45423 NZ_CP006696:c180361-180134 [Xylella fastidiosa subsp. sandyi Ann-1]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HDH1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7TPD2

References