Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2773745..2774405 Replicon chromosome
Accession NZ_CP006692
Organism Salmonella bongori serovar 48:z41:-- str. RKS3044

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag N643_RS12900 Protein ID WP_000244759.1
Coordinates 2773745..2774158 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N643_RS12905 Protein ID WP_000351186.1
Coordinates 2774139..2774405 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N643_RS12880 2769687..2771420 - 1734 WP_038392510.1 single-stranded-DNA-specific exonuclease RecJ -
N643_RS12885 2771426..2772139 - 714 WP_038392512.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N643_RS12890 2772163..2773059 - 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
N643_RS12895 2773172..2773693 + 522 WP_001055887.1 flavodoxin FldB -
N643_RS12900 2773745..2774158 - 414 WP_000244759.1 protein YgfX Toxin
N643_RS12905 2774139..2774405 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N643_RS12915 2774652..2775632 + 981 WP_038392516.1 tRNA-modifying protein YgfZ -
N643_RS12920 2775683..2776342 - 660 WP_038392517.1 hemolysin III family protein -
N643_RS12925 2776506..2776817 - 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
N643_RS12930 2776975..2778408 + 1434 WP_038392518.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T45415 WP_000244759.1 NZ_CP006692:c2774158-2773745 [Salmonella bongori serovar 48:z41:-- str. RKS3044]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T45415 NZ_CP006692:c2774158-2773745 [Salmonella bongori serovar 48:z41:-- str. RKS3044]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTAATTTTATTGATGCCCTGGCCGTTGAGTTATACCCCATTGTGGATGATGCTACTGTCGCTGGTGGTGTTTGACTGCG
TTCGTAGTCAGCGCCGGATTAATACCTGTCAGGGAGAGATCAAGCTGCTAATGGATGGGCGCTTACGCTGGCAGGGGGAA
GACTGGGTGCTCCTGCGCCCGCCCTGGTTACTGAACAGCGGGATGGTGTTGCGTTTACGCGCCGAGTCCGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAGGCGGAATGGCGTGAGTTACGCCGTGTCATGTTGCAACAACCACTAT
CGGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT45415 WP_000351186.1 NZ_CP006692:c2774405-2774139 [Salmonella bongori serovar 48:z41:-- str. RKS3044]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT45415 NZ_CP006692:c2774405-2774139 [Salmonella bongori serovar 48:z41:-- str. RKS3044]
ATGGATATTCACAATAAAGCACGTATTCATTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGCGACGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAGCTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References