Detailed information of TA system TA045393

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1119479..1120142
• Replicon: chromosome
• Accession: NZ_CP006664
• Organism: Edwardsiella anguillarum ET080813 strain 80813

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ETEE_RS05110
• Protein ID: WP_034164690.1
• Coordinates: 1119479..1119895 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: ETEE_RS05115
• Protein ID: WP_012849755.1
• Coordinates: 1119876..1120142 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETEE_RS05090	1115409..1117142	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
ETEE_RS05095	1117147..1117863	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ETEE_RS05100	1117891..1118790	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
ETEE_RS05105	1118942..1119454	+	513	WP_034164689.1	flavodoxin FldB	-
ETEE_RS05110	1119479..1119895	-	417	WP_034164690.1	protein YgfX	Toxin
ETEE_RS05115	1119876..1120142	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
ETEE_RS05120	1120491..1121489	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
ETEE_RS05125	1121531..1122355	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
ETEE_RS05130	1122512..1123384	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
ETEE_RS05135	1123993..1124643	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T45393 WP_034164690.1 NZ_CP006664:c1119895-1119479 [Edwardsiella anguillarum ET080813]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T45393 NZ_CP006664:c1119895-1119479 [Edwardsiella anguillarum ET080813]
GTGGTCCTTTGGCGCTGTAACGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTTTT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGCATTCTGGCTGGTTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGTCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGACGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGGCGCCCCTGGGTTAGCGATCTGGGGGCGCTGCTGATTCTGCAGAGTACCCATGGTGTACCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGAGAAGAGTGGGGGCAGCTGCGCCGCGCGCTGCTCGATACGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT45393 WP_012849755.1 NZ_CP006664:c1120142-1119876 [Edwardsiella anguillarum ET080813]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT45393 NZ_CP006664:c1120142-1119876 [Edwardsiella anguillarum ET080813]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCGATTATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGCGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGACGACGCTGATCTGGCCCGTATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8