45374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 523155..523671 Replicon chromosome
Accession NZ_CP006659
Organism Klebsiella pneumoniae strain ATCC BAA-2146

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag kpn2146_RS02635 Protein ID WP_002886902.1
Coordinates 523387..523671 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag kpn2146_RS02630 Protein ID WP_002886901.1
Coordinates 523155..523397 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
kpn2146_RS02615 519184..519924 + 741 WP_002886899.1 KDGP aldolase family protein -
kpn2146_RS02620 519990..521144 + 1155 WP_002886900.1 lactonase family protein -
kpn2146_RS02625 521167..523077 + 1911 WP_004152270.1 BglG family transcription antiterminator -
kpn2146_RS02630 523155..523397 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
kpn2146_RS02635 523387..523671 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
kpn2146_RS02640 523675..524139 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
kpn2146_RS02645 524380..526518 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
kpn2146_RS02655 526875..527618 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
kpn2146_RS32185 527621..527794 - 174 WP_002886906.1 hypothetical protein -
kpn2146_RS02665 527879..528187 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T45374 WP_002886902.1 NZ_CP006659:523387-523671 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T45374 NZ_CP006659:523387-523671 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT45374 WP_002886901.1 NZ_CP006659:523155-523397 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT45374 NZ_CP006659:523155-523397 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References