Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4958891..4959501 Replicon chromosome
Accession NZ_CP006644
Organism Sphingomonas sanxanigenens DSM 19645 = NX02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NX02_RS22725 Protein ID WP_025294461.1
Coordinates 4959313..4959501 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NX02_RS22720 Protein ID WP_025294460.1
Coordinates 4958891..4959280 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX02_RS22690 4954607..4954897 - 291 WP_039996792.1 hypothetical protein -
NX02_RS22695 4955167..4955673 + 507 WP_025294456.1 hypothetical protein -
NX02_RS22700 4955728..4957062 - 1335 WP_084718040.1 HAMP domain-containing protein -
NX02_RS22705 4957128..4957847 - 720 WP_025294458.1 response regulator -
NX02_RS22710 4958051..4958617 - 567 WP_025294459.1 EF-hand domain-containing protein -
NX02_RS22720 4958891..4959280 - 390 WP_025294460.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NX02_RS22725 4959313..4959501 - 189 WP_025294461.1 type II toxin-antitoxin system HicA family toxin Toxin
NX02_RS22730 4959598..4960776 + 1179 WP_025294462.1 serine hydrolase -
NX02_RS22735 4960871..4961656 + 786 WP_025294463.1 GNAT family N-acetyltransferase -
NX02_RS22740 4961620..4962345 - 726 WP_025294464.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
NX02_RS22745 4962381..4963037 - 657 WP_025294465.1 glutathione S-transferase -
NX02_RS22750 4963161..4964375 + 1215 WP_025294466.1 polyhydroxyalkanoate depolymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-120)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6805.89 Da        Isoelectric Point: 10.9765

>T45370 WP_025294461.1 NZ_CP006644:c4959501-4959313 [Sphingomonas sanxanigenens DSM 19645 = NX02]
ISSRIVIRKIEADGWYEVRQSGSHIHFRHPSKPGTATVPHPVKDLPLGTLKSIAKQTGVPLP

Download         Length: 189 bp

>T45370 NZ_CP006644:c4959501-4959313 [Sphingomonas sanxanigenens DSM 19645 = NX02]
ATCAGTAGCCGAATTGTGATCCGCAAGATCGAGGCAGATGGTTGGTACGAGGTGAGGCAAAGCGGCAGCCACATTCATTT
CCGTCATCCGTCCAAGCCCGGTACGGCCACCGTGCCGCATCCGGTGAAGGATCTGCCGTTGGGCACGCTCAAGAGCATAG
CGAAACAAACCGGCGTGCCGCTGCCCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13813.37 Da        Isoelectric Point: 4.6155

>AT45370 WP_025294460.1 NZ_CP006644:c4959280-4958891 [Sphingomonas sanxanigenens DSM 19645 = NX02]
MATAYYPAIIERGNDGFGVTFPDLPGCTSFGTSLQDAARNAEEALDGHLNVAAEYGDSIPEPSNLDEIGHHPDVDEVARL
LVRVERPGRAVRLNITLDEGLLARIDRVAKNRSGFLAEAARRALQSAGA

Download         Length: 390 bp

>AT45370 NZ_CP006644:c4959280-4958891 [Sphingomonas sanxanigenens DSM 19645 = NX02]
ATGGCAACCGCATATTATCCTGCCATCATCGAGCGCGGCAATGACGGGTTTGGCGTTACCTTCCCCGATCTGCCGGGTTG
CACATCGTTCGGCACCAGCCTGCAGGACGCGGCGCGCAACGCCGAGGAGGCGCTCGACGGACATCTGAACGTCGCGGCCG
AATATGGCGATTCGATCCCCGAGCCGTCCAACCTCGACGAGATCGGGCATCATCCGGATGTGGATGAGGTCGCCAGGCTG
CTGGTGCGGGTCGAGCGGCCGGGGCGGGCGGTACGGCTCAACATCACGCTTGATGAAGGGTTGCTCGCGCGGATCGATCG
TGTCGCCAAGAATCGTTCGGGCTTCCTCGCCGAAGCGGCTCGGCGCGCGCTGCAGTCGGCCGGAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References