Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ParST/RES-Xre |
| Location | 2333334..2334475 | Replicon | chromosome |
| Accession | NZ_CP006644 | ||
| Organism | Sphingomonas sanxanigenens DSM 19645 = NX02 | ||
Toxin (Protein)
| Gene name | ParT | Uniprot ID | - |
| Locus tag | NX02_RS10735 | Protein ID | WP_025292199.1 |
| Coordinates | 2333984..2334475 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | ParS | Uniprot ID | - |
| Locus tag | NX02_RS10730 | Protein ID | WP_084717703.1 |
| Coordinates | 2333334..2333987 (+) | Length | 218 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NX02_RS10715 | 2328500..2329330 | + | 831 | WP_025292195.1 | alpha/beta hydrolase | - |
| NX02_RS10720 | 2329535..2331577 | - | 2043 | WP_047099774.1 | TonB-dependent receptor | - |
| NX02_RS10725 | 2331744..2333264 | - | 1521 | WP_025292197.1 | aldehyde dehydrogenase family protein | - |
| NX02_RS10730 | 2333334..2333987 | + | 654 | WP_084717703.1 | MbcA/ParS/Xre antitoxin family protein | Antitoxin |
| NX02_RS10735 | 2333984..2334475 | + | 492 | WP_025292199.1 | RES family NAD+ phosphorylase | Toxin |
| NX02_RS10740 | 2334614..2334874 | - | 261 | WP_025292200.1 | hypothetical protein | - |
| NX02_RS10745 | 2334871..2335923 | - | 1053 | WP_025292201.1 | Glu/Leu/Phe/Val dehydrogenase | - |
| NX02_RS10750 | 2336052..2336513 | + | 462 | WP_025292202.1 | Lrp/AsnC family transcriptional regulator | - |
| NX02_RS10755 | 2336737..2337819 | + | 1083 | WP_025292203.1 | low specificity L-threonine aldolase | - |
| NX02_RS10760 | 2337809..2338792 | - | 984 | WP_025292204.1 | oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17553.89 Da Isoelectric Point: 5.7334
>T45368 WP_025292199.1 NZ_CP006644:2333984-2334475 [Sphingomonas sanxanigenens DSM 19645 = NX02]
VSRQVYRIGTDTKLYTADDMTGTGAKISGGRWNDVGVAVVYASPTRALACLETFVHLNAGGLPLNRYLVEIEIPDDVWAA
AENATAASLAVGWDAEPAGMISISFGTNWANSGRSALSLIPSIIVPEEQNVLINPAHPDAARITAQKVRKWLYDPRMDRS
VKS
VSRQVYRIGTDTKLYTADDMTGTGAKISGGRWNDVGVAVVYASPTRALACLETFVHLNAGGLPLNRYLVEIEIPDDVWAA
AENATAASLAVGWDAEPAGMISISFGTNWANSGRSALSLIPSIIVPEEQNVLINPAHPDAARITAQKVRKWLYDPRMDRS
VKS
Download Length: 492 bp
>T45368 NZ_CP006644:2333984-2334475 [Sphingomonas sanxanigenens DSM 19645 = NX02]
GTGAGCCGGCAGGTCTATCGGATCGGCACGGACACAAAGCTCTACACCGCGGACGATATGACGGGAACGGGCGCCAAGAT
ATCGGGCGGCCGCTGGAATGATGTCGGCGTCGCCGTCGTTTACGCGTCCCCGACTCGTGCCCTGGCGTGTCTGGAGACCT
TCGTTCACCTGAATGCCGGCGGTCTGCCGCTGAACCGCTACCTCGTCGAGATCGAGATTCCGGACGATGTGTGGGCCGCC
GCCGAAAACGCCACAGCGGCCTCGCTCGCGGTCGGCTGGGACGCGGAGCCAGCGGGAATGATCAGCATATCGTTCGGGAC
GAACTGGGCGAACAGCGGACGGTCGGCACTGTCGCTAATTCCCTCGATCATCGTGCCCGAAGAGCAGAATGTGCTCATCA
ATCCGGCTCATCCTGACGCCGCGCGGATCACGGCGCAGAAGGTTCGCAAATGGCTCTATGATCCGCGGATGGATCGCAGC
GTGAAAAGCTGA
GTGAGCCGGCAGGTCTATCGGATCGGCACGGACACAAAGCTCTACACCGCGGACGATATGACGGGAACGGGCGCCAAGAT
ATCGGGCGGCCGCTGGAATGATGTCGGCGTCGCCGTCGTTTACGCGTCCCCGACTCGTGCCCTGGCGTGTCTGGAGACCT
TCGTTCACCTGAATGCCGGCGGTCTGCCGCTGAACCGCTACCTCGTCGAGATCGAGATTCCGGACGATGTGTGGGCCGCC
GCCGAAAACGCCACAGCGGCCTCGCTCGCGGTCGGCTGGGACGCGGAGCCAGCGGGAATGATCAGCATATCGTTCGGGAC
GAACTGGGCGAACAGCGGACGGTCGGCACTGTCGCTAATTCCCTCGATCATCGTGCCCGAAGAGCAGAATGTGCTCATCA
ATCCGGCTCATCCTGACGCCGCGCGGATCACGGCGCAGAAGGTTCGCAAATGGCTCTATGATCCGCGGATGGATCGCAGC
GTGAAAAGCTGA
Antitoxin
Download Length: 218 a.a. Molecular weight: 24096.44 Da Isoelectric Point: 10.0437
>AT45368 WP_084717703.1 NZ_CP006644:2333334-2333987 [Sphingomonas sanxanigenens DSM 19645 = NX02]
MRPSVVCASHPVVCTARRRQRQWRWRKQRQADARKGNSASILANSDHLIHTVAQRSRVVTSVASTRTISETPIGRSFDYI
DLFRAEPVERIEFIKAGVSARAVKLFISELHFDQNVLIEALSLKTATLNRKAARNELLSAEDSERVVGLAKLVGQLEAMI
EDSGGAEGFDASEWLSRWLRDPLPALNGARPIEFLDTMEGQALVSRALSQIQSGAYA
MRPSVVCASHPVVCTARRRQRQWRWRKQRQADARKGNSASILANSDHLIHTVAQRSRVVTSVASTRTISETPIGRSFDYI
DLFRAEPVERIEFIKAGVSARAVKLFISELHFDQNVLIEALSLKTATLNRKAARNELLSAEDSERVVGLAKLVGQLEAMI
EDSGGAEGFDASEWLSRWLRDPLPALNGARPIEFLDTMEGQALVSRALSQIQSGAYA
Download Length: 654 bp
>AT45368 NZ_CP006644:2333334-2333987 [Sphingomonas sanxanigenens DSM 19645 = NX02]
ATGAGACCTTCGGTCGTTTGCGCGAGCCATCCTGTTGTGTGCACGGCCAGGCGGCGACAACGCCAATGGCGATGGCGGAA
GCAGCGTCAGGCGGATGCCCGAAAGGGAAATTCAGCGTCTATCCTTGCGAATTCCGATCATTTGATCCATACAGTTGCTC
AAAGGAGCAGAGTCGTGACGTCGGTCGCCAGCACCCGTACCATCTCGGAGACCCCGATCGGTCGGTCTTTCGACTATATC
GATCTGTTCCGGGCAGAGCCCGTCGAGCGTATCGAGTTCATCAAGGCGGGCGTATCCGCTAGGGCGGTGAAGCTCTTCAT
TTCCGAACTGCATTTCGATCAGAACGTGCTGATCGAAGCGCTCAGCCTCAAGACCGCCACGCTCAATCGAAAAGCGGCAC
GCAACGAGCTTCTGTCGGCCGAAGACAGCGAGCGCGTCGTCGGACTGGCGAAGCTGGTCGGCCAACTCGAGGCGATGATC
GAGGATAGCGGCGGCGCCGAGGGTTTCGACGCTTCGGAGTGGCTATCCCGCTGGCTTCGGGATCCGCTGCCCGCGCTCAA
CGGTGCGAGGCCGATCGAGTTTCTCGACACGATGGAAGGCCAGGCGCTCGTTTCCAGAGCGCTCTCGCAGATCCAGAGCG
GAGCCTATGCGTGA
ATGAGACCTTCGGTCGTTTGCGCGAGCCATCCTGTTGTGTGCACGGCCAGGCGGCGACAACGCCAATGGCGATGGCGGAA
GCAGCGTCAGGCGGATGCCCGAAAGGGAAATTCAGCGTCTATCCTTGCGAATTCCGATCATTTGATCCATACAGTTGCTC
AAAGGAGCAGAGTCGTGACGTCGGTCGCCAGCACCCGTACCATCTCGGAGACCCCGATCGGTCGGTCTTTCGACTATATC
GATCTGTTCCGGGCAGAGCCCGTCGAGCGTATCGAGTTCATCAAGGCGGGCGTATCCGCTAGGGCGGTGAAGCTCTTCAT
TTCCGAACTGCATTTCGATCAGAACGTGCTGATCGAAGCGCTCAGCCTCAAGACCGCCACGCTCAATCGAAAAGCGGCAC
GCAACGAGCTTCTGTCGGCCGAAGACAGCGAGCGCGTCGTCGGACTGGCGAAGCTGGTCGGCCAACTCGAGGCGATGATC
GAGGATAGCGGCGGCGCCGAGGGTTTCGACGCTTCGGAGTGGCTATCCCGCTGGCTTCGGGATCCGCTGCCCGCGCTCAA
CGGTGCGAGGCCGATCGAGTTTCTCGACACGATGGAAGGCCAGGCGCTCGTTTCCAGAGCGCTCTCGCAGATCCAGAGCG
GAGCCTATGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|