Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4495982..4496817 Replicon chromosome
Accession NZ_CP006636
Organism Escherichia coli PCN061

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag PCN061_RS22495 Protein ID WP_001094443.1
Coordinates 4496440..4496817 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag PCN061_RS22490 Protein ID WP_001285607.1
Coordinates 4495982..4496350 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCN061_RS22455 4491873..4492553 + 681 WP_001282919.1 WYL domain-containing protein -
PCN061_RS22460 4492701..4493378 + 678 WP_001097301.1 hypothetical protein -
PCN061_RS22465 4493408..4493617 + 210 WP_032150870.1 DUF905 family protein -
PCN061_RS22470 4493707..4494525 + 819 WP_001175175.1 DUF945 domain-containing protein -
PCN061_RS22475 4494617..4495102 + 486 WP_000213716.1 antirestriction protein -
PCN061_RS22480 4495118..4495594 + 477 WP_001186780.1 RadC family protein -
PCN061_RS22485 4495681..4495902 + 222 WP_000692350.1 DUF987 domain-containing protein -
PCN061_RS22490 4495982..4496350 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PCN061_RS22495 4496440..4496817 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
PCN061_RS22500 4496814..4497302 + 489 WP_000761685.1 hypothetical protein -
PCN061_RS22505 4497322..4497519 + 198 WP_001327226.1 DUF957 domain-containing protein -
PCN061_RS29460 4497604..4497750 + 147 WP_001290178.1 hypothetical protein -
PCN061_RS22510 4498178..4498543 + 366 Protein_4232 DUF4102 domain-containing protein -
PCN061_RS28640 4498544..4498723 + 180 Protein_4233 IS21 family transposase -
PCN061_RS22515 4498732..4499178 + 447 Protein_4234 IS21-like element IS100kyp family helper ATPase IstB -
PCN061_RS22520 4499260..4499664 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
PCN061_RS22525 4499661..4500008 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
PCN061_RS22530 4500057..4501406 + 1350 Protein_4237 IS66-like element ISEc22 family transposase -
PCN061_RS29465 4501401..4501549 + 149 Protein_4238 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T45352 WP_001094443.1 NZ_CP006636:4496440-4496817 [Escherichia coli PCN061]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T45352 NZ_CP006636:4496440-4496817 [Escherichia coli PCN061]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT45352 WP_001285607.1 NZ_CP006636:4495982-4496350 [Escherichia coli PCN061]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT45352 NZ_CP006636:4495982-4496350 [Escherichia coli PCN061]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References