Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1937997..1938794 Replicon chromosome
Accession NZ_CP006630
Organism Staphylococcus aureus subsp. aureus SA268

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag SA268_RS09615 Protein ID WP_000525009.1
Coordinates 1938333..1938794 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag SA268_RS09610 Protein ID WP_001260487.1
Coordinates 1937997..1938320 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA268_RS09550 1933294..1933737 - 444 WP_001099007.1 single-stranded DNA-binding protein -
SA268_RS09555 1933734..1934384 - 651 WP_000840496.1 ERF family protein -
SA268_RS09560 1934385..1934921 - 537 WP_001004336.1 host-nuclease inhibitor Gam family protein -
SA268_RS09565 1934934..1935194 - 261 WP_001556704.1 DUF1108 family protein -
SA268_RS09570 1935199..1935516 - 318 WP_000829613.1 hypothetical protein -
SA268_RS09575 1935605..1935766 - 162 WP_000048124.1 DUF1270 family protein -
SA268_RS09580 1935780..1935989 - 210 WP_000455727.1 hypothetical protein -
SA268_RS09585 1936002..1936715 - 714 WP_031925041.1 ORF6C domain-containing protein -
SA268_RS09590 1936772..1936981 + 210 WP_000772137.1 hypothetical protein -
SA268_RS09595 1936974..1937114 - 141 WP_000939495.1 hypothetical protein -
SA268_RS09600 1937129..1937572 - 444 WP_000435360.1 hypothetical protein -
SA268_RS09605 1937585..1937833 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
SA268_RS09610 1937997..1938320 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
SA268_RS09615 1938333..1938794 + 462 WP_000525009.1 hypothetical protein Toxin
SA268_RS09620 1938812..1939327 + 516 WP_031790084.1 hypothetical protein -
SA268_RS09625 1939389..1940438 + 1050 WP_000146088.1 site-specific integrase -
SA268_RS09670 1941716..1942270 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp 1889218..1942270 53052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T45286 WP_000525009.1 NZ_CP006630:1938333-1938794 [Staphylococcus aureus subsp. aureus SA268]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T45286 NZ_CP006630:1938333-1938794 [Staphylococcus aureus subsp. aureus SA268]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT45286 WP_001260487.1 NZ_CP006630:1937997-1938320 [Staphylococcus aureus subsp. aureus SA268]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT45286 NZ_CP006630:1937997-1938320 [Staphylococcus aureus subsp. aureus SA268]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References