Detailed information of TA system TA045284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 860278..860810
• Replicon: chromosome
• Accession: NZ_CP006630
• Organism: Staphylococcus aureus subsp. aureus SA268

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SA268_RS04140
• Protein ID: WP_001103942.1
• Coordinates: 860490..860810 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SA268_RS04135
• Protein ID: WP_001058486.1
• Coordinates: 860278..860487 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA268_RS04090	855298..856518	-	1221	WP_000266157.1	site-specific integrase	-
SA268_RS04095	856606..857334	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
SA268_RS04100	857358..858086	-	729	WP_038412484.1	staphylococcal enterotoxin type Q	-
SA268_RS04105	858156..858587	-	432	WP_001228759.1	hypothetical protein	-
SA268_RS04110	858604..859062	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SA268_RS04115	859074..859406	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SA268_RS04120	859599..859862	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SA268_RS04125	859855..860127	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SA268_RS04130	860139..860285	+	147	WP_000784875.1	hypothetical protein	-
SA268_RS04135	860278..860487	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SA268_RS04140	860490..860810	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SA268_RS04145	860874..861743	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
SA268_RS04150	861760..863229	+	1470	WP_000390454.1	virulence-associated E family protein	-
SA268_RS04155	863515..863877	+	363	WP_001039168.1	hypothetical protein	-
SA268_RS04160	863879..864163	+	285	WP_000998181.1	hypothetical protein	-
SA268_RS04165	864160..864801	+	642	WP_001019764.1	hypothetical protein	-
SA268_RS04170	865318..865659	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / selk / selq / seb	828645..870610	41965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T45284 WP_001103942.1 NZ_CP006630:860490-860810 [Staphylococcus aureus subsp. aureus SA268]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T45284 NZ_CP006630:860490-860810 [Staphylococcus aureus subsp. aureus SA268]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT45284 WP_001058486.1 NZ_CP006630:860278-860487 [Staphylococcus aureus subsp. aureus SA268]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT45284 NZ_CP006630:860278-860487 [Staphylococcus aureus subsp. aureus SA268]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4