Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 842583..843060 Replicon chromosome
Accession NZ_CP006630
Organism Staphylococcus aureus subsp. aureus SA268

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA268_RS03985 Protein ID WP_000052076.1
Coordinates 842583..842771 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA268_RS03990 Protein ID WP_001059690.1
Coordinates 842800..843060 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA268_RS03955 838621..839091 + 471 WP_000824462.1 hypothetical protein -
SA268_RS03960 839432..840118 + 687 WP_001823812.1 thermonuclease family protein -
SA268_RS03965 840475..840675 + 201 WP_001059082.1 cold-shock protein -
SA268_RS03970 841174..841392 - 219 WP_000005888.1 hypothetical protein -
SA268_RS03975 841454..841738 - 285 WP_001004397.1 hypothetical protein -
SA268_RS03980 841826..842395 - 570 WP_001106657.1 hypothetical protein -
SA268_RS03985 842583..842771 - 189 WP_000052076.1 hypothetical protein Toxin
SA268_RS03990 842800..843060 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA268_RS03995 843401..843604 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA268_RS04000 843601..843837 - 237 WP_000368687.1 hypothetical protein -
SA268_RS04005 844062..844643 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
SA268_RS04010 844716..845333 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
SA268_RS04015 845489..845983 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SA268_RS04020 846382..846804 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SA268_RS04025 846952..847668 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / selk / selq / seb 828645..870610 41965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T45283 WP_000052076.1 NZ_CP006630:c842771-842583 [Staphylococcus aureus subsp. aureus SA268]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T45283 NZ_CP006630:c842771-842583 [Staphylococcus aureus subsp. aureus SA268]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT45283 WP_001059690.1 NZ_CP006630:c843060-842800 [Staphylococcus aureus subsp. aureus SA268]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT45283 NZ_CP006630:c843060-842800 [Staphylococcus aureus subsp. aureus SA268]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References