Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4990446..4991199 Replicon chromosome
Accession NZ_CP006580
Organism Enterobacter ludwigii strain P101

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M942_RS24260 Protein ID WP_047356150.1
Coordinates 4990837..4991199 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag M942_RS24255 Protein ID WP_196298450.1
Coordinates 4990446..4990772 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M942_RS24215 4985704..4986426 + 723 WP_025206342.1 DUF3944 domain-containing protein -
M942_RS24220 4986447..4987133 + 687 WP_025206343.1 WYL domain-containing protein -
M942_RS24225 4987142..4987582 + 441 WP_025206344.1 hypothetical protein -
M942_RS24230 4987618..4987980 + 363 WP_025206345.1 hypothetical protein -
M942_RS24235 4988235..4989075 + 841 Protein_4759 DUF945 domain-containing protein -
M942_RS24240 4989184..4989663 + 480 WP_025206346.1 antirestriction protein -
M942_RS24245 4989675..4990154 + 480 WP_025206347.1 DNA repair protein RadC -
M942_RS24250 4990169..4990390 + 222 WP_025206348.1 DUF987 domain-containing protein -
M942_RS24255 4990446..4990772 + 327 WP_196298450.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M942_RS24260 4990837..4991199 + 363 WP_047356150.1 TA system toxin CbtA family protein Toxin
M942_RS24265 4991298..4991675 + 378 WP_025206351.1 TA system toxin CbtA family protein -
M942_RS24270 4991672..4992163 + 492 WP_025206352.1 hypothetical protein -
M942_RS24275 4992192..4992404 + 213 WP_025202711.1 DUF957 domain-containing protein -
M942_RS27370 4992320..4993041 + 722 Protein_4768 DUF4055 domain-containing protein -
M942_RS28010 4993038..4993241 + 204 WP_025206354.1 hypothetical protein -
M942_RS27100 4993201..4993287 + 87 Protein_4770 tail fiber assembly protein -
M942_RS24290 4993405..4994472 - 1068 WP_025206355.1 hypothetical protein -
M942_RS24295 4995041..4995625 - 585 WP_047356287.1 disulfide bond formation protein B -
M942_RS24300 4995622..4995864 - 243 WP_025206357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4971560..5007205 35645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(15-105)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13202.63 Da        Isoelectric Point: 4.4118

>T45282 WP_047356150.1 NZ_CP006580:4990837-4991199 [Enterobacter ludwigii]
MYPQNAAAEIERLTHVSPVAVWQRLLTYLLERHYGLALNDTPFGDDDAIQECIDSGDPLVDALNEMAEDNNLERTDNRGK
SFLSVSSRLTPADIRSAQNAVGLADSRTTLIINARSSARS

Download         Length: 363 bp

>T45282 NZ_CP006580:4990837-4991199 [Enterobacter ludwigii]
CTGTATCCGCAAAATGCGGCTGCTGAGATTGAGCGGTTAACGCATGTATCACCCGTTGCCGTGTGGCAGCGCCTCCTGAC
TTATCTGCTGGAGCGTCACTACGGTCTGGCGCTCAACGACACGCCGTTTGGCGATGACGATGCCATTCAGGAATGCATTG
ACTCCGGGGATCCGCTGGTTGACGCCCTGAATGAGATGGCTGAAGACAACAATCTGGAACGTACTGATAATCGGGGAAAA
TCATTCCTGTCCGTCTCGTCGCGGCTCACGCCAGCAGATATCCGGAGCGCCCAAAACGCAGTGGGTCTGGCAGACAGTCG
CACCACCCTCATTATCAACGCCCGGTCGTCAGCCAGAAGCTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12036.77 Da        Isoelectric Point: 6.3122

>AT45282 WP_196298450.1 NZ_CP006580:4990446-4990772 [Enterobacter ludwigii]
IAEPWWGLKRDFTPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPVLLKQLELMLISGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYMTIYPTPAATA

Download         Length: 327 bp

>AT45282 NZ_CP006580:4990446-4990772 [Enterobacter ludwigii]
ATCGCTGAGCCATGGTGGGGACTTAAACGCGATTTTACCCCGTGTTTTGGCGCACGCCTGGTGCAGGAGGGCAACCGCCT
GCACTACCTGGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTCGATCAGGCGTTTCCGG
TATTGCTCAAACAACTGGAGCTGATGCTCATTTCCGGTGAGCTCAATCCCTGCCATCAGCACTGCGTCACGCTTTACGCA
AAAGGGCTGACCTGTGAGGCCGACTCCCTCGGCTCACATGGTTACGTGTACATGACGATTTACCCCACACCTGCAGCAAC
CGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References