Detailed information of TA system TA045281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4781990..4782506
• Replicon: chromosome
• Accession: NZ_CP006580
• Organism: Enterobacter ludwigii strain P101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M942_RS23215
• Protein ID: WP_025205770.1
• Coordinates: 4781990..4782274 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: M942_RS23220
• Protein ID: WP_025205772.1
• Coordinates: 4782264..4782506 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M942_RS23200	4778305..4778877	+	573	WP_025205763.1	PTS sugar transporter subunit IIA	-
M942_RS23205	4779245..4781383	+	2139	WP_025205765.1	anaerobic ribonucleoside-triphosphate reductase	-
M942_RS23210	4781522..4781986	+	465	WP_025205767.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
M942_RS23215	4781990..4782274	-	285	WP_025205770.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M942_RS23220	4782264..4782506	-	243	WP_025205772.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
M942_RS23225	4782584..4784494	-	1911	WP_025205774.1	BglG family transcription antiterminator	-
M942_RS23230	4784514..4785650	-	1137	WP_025205775.1	lactonase family protein	-
M942_RS23235	4785769..4786509	-	741	WP_014168382.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10930.70 Da
• Isoelectric Point: 10.1038

>T45281 WP_025205770.1 NZ_CP006580:c4782274-4781990 [Enterobacter ludwigii]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPRVESARLYGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIGK
RENSAVYHDVNKRL

Nucleotide

• Length: 285 bp

>T45281 NZ_CP006580:c4782274-4781990 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGTATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTAAG
AGAGAGAATTCAGCCGTTTATCATGACGTAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9057.44 Da
• Isoelectric Point: 5.1088

>AT45281 WP_025205772.1 NZ_CP006580:c4782506-4782264 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTARERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT45281 NZ_CP006580:c4782506-4782264 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTGCTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGCCCGTGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA