Detailed information of TA system TA045280

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4723551..4724339
• Replicon: chromosome
• Accession: NZ_CP006580
• Organism: Enterobacter ludwigii strain P101

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: M942_RS22990
• Protein ID: WP_025205715.1
• Coordinates: 4723962..4724339 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: M942_RS22985
• Protein ID: WP_025205713.1
• Coordinates: 4723551..4723910 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M942_RS22950	4719961..4720425	+	465	WP_025205705.1	hypothetical protein	-
M942_RS22955	4720480..4720839	+	360	WP_025205706.1	hypothetical protein	-
M942_RS22960	4720920..4721132	+	213	WP_025205707.1	hypothetical protein	-
M942_RS22965	4721243..4722061	+	819	WP_025205708.1	DUF945 domain-containing protein	-
M942_RS22970	4722320..4722802	+	483	WP_025205710.1	antirestriction protein	-
M942_RS22975	4722814..4723293	+	480	WP_025205711.1	DNA repair protein RadC	-
M942_RS22980	4723307..4723528	+	222	WP_025205712.1	DUF987 domain-containing protein	-
M942_RS22985	4723551..4723910	+	360	WP_025205713.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
M942_RS22990	4723962..4724339	+	378	WP_025205715.1	TA system toxin CbtA family protein	Toxin
M942_RS22995	4724336..4724827	+	492	WP_025205716.1	hypothetical protein	-
M942_RS23000	4724857..4725060	+	204	WP_025205717.1	DUF957 domain-containing protein	-
M942_RS23005	4725110..4726087	-	978	WP_025205718.1	glycosyltransferase	-
M942_RS27350	4726478..4728009	+	1532	WP_131631852.1	IS3 family transposase	-
M942_RS23015	4728299..4729225	-	927	WP_025205719.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4703868..4741702	37834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13994.86 Da
• Isoelectric Point: 8.0503

>T45280 WP_025205715.1 NZ_CP006580:4723962-4724339 [Enterobacter ludwigii]
MQTQRLSSTGETSPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIEASISLCDAVNFIVEKYALVRIDRRGF
NAETQSPLLTSIDILRARKATGLMTRNGYRMVTDITTGKYSGATQ

Nucleotide

• Length: 378 bp

>T45280 NZ_CP006580:4723962-4724339 [Enterobacter ludwigii]
ATGCAAACTCAAAGACTATCCTCAACGGGGGAGACCTCACCACGTCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGCTGGATCGTCATTACGGCCTGACGCTCAACGACACGCCTTTCGGCAATGATGGTGTGATCCAGGAACATATCG
AAGCCAGTATCTCACTGTGCGACGCCGTGAATTTTATCGTGGAAAAGTACGCCCTGGTGCGCATCGATCGTCGCGGTTTT
AACGCAGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACGCGCAA
CGGCTACAGAATGGTAACCGATATCACCACCGGCAAATACAGCGGGGCGACTCAATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13124.94 Da
• Isoelectric Point: 6.9549

>AT45280 WP_025205713.1 NZ_CP006580:4723551-4723910 [Enterobacter ludwigii]
MQNTTNVANHDIAEPWWGLKPTVTPCFGARLVQEGNRLHYLADRANITGTFSDADLRHLDQTFPLLLKQLELMLVSGELN
PRHQHGVTLYAKGLTCNANTLGSCGYVYIALYPTPATTA

Nucleotide

• Length: 360 bp

>AT45280 NZ_CP006580:4723551-4723910 [Enterobacter ludwigii]
ATGCAGAACACAACAAACGTAGCAAATCATGATATTGCCGAACCCTGGTGGGGACTTAAACCCACCGTCACGCCGTGTTT
TGGCGCACGCCTGGTGCAGGAAGGCAACCGCCTGCATTACCTGGCTGACCGCGCCAATATCACCGGCACCTTTAGTGACG
CGGATTTACGCCATCTCGACCAGACATTTCCGCTGCTGCTCAAACAGCTTGAACTGATGCTGGTTTCCGGTGAACTCAAT
CCCCGCCATCAGCACGGTGTCACGCTCTACGCAAAAGGGCTAACATGCAATGCCAACACCCTGGGTAGTTGCGGCTATGT
CTATATTGCGCTTTACCCAACACCTGCAACAACCGCGTAA