Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4716998..4717525 Replicon chromosome
Accession NZ_CP006580
Organism Enterobacter ludwigii strain P101

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M942_RS22930 Protein ID WP_025205702.1
Coordinates 4716998..4717273 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M942_RS22935 Protein ID WP_025205703.1
Coordinates 4717277..4717525 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M942_RS22920 4713329..4715689 - 2361 WP_025205700.1 type I restriction-modification system subunit M -
M942_RS22925 4716086..4716883 - 798 WP_025205701.1 helix-turn-helix transcriptional regulator -
M942_RS22930 4716998..4717273 - 276 WP_025205702.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M942_RS22935 4717277..4717525 - 249 WP_025205703.1 ribbon-helix-helix domain-containing protein Antitoxin
M942_RS22940 4717595..4718167 - 573 Protein_4503 DUF4942 domain-containing protein -
M942_RS22950 4719961..4720425 + 465 WP_025205705.1 hypothetical protein -
M942_RS22955 4720480..4720839 + 360 WP_025205706.1 hypothetical protein -
M942_RS22960 4720920..4721132 + 213 WP_025205707.1 hypothetical protein -
M942_RS22965 4721243..4722061 + 819 WP_025205708.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4703868..4741702 37834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10938.33 Da        Isoelectric Point: 5.1447

>T45279 WP_025205702.1 NZ_CP006580:c4717273-4716998 [Enterobacter ludwigii]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITCCAGLTAHPAIGVQQARYEPREVRKVLFDDYEVHYELRANDIN
IVDLWHTKEER

Download         Length: 276 bp

>T45279 NZ_CP006580:c4717273-4716998 [Enterobacter ludwigii]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAACGTATCTACCGTTTCGCCCTTCAGTATAGCCGCCAGCA
CGCTGATGATGTATTGGATCGCCTGATTACTTGCTGCGCAGGCCTTACAGCGCATCCGGCAATTGGTGTGCAGCAGGCTC
GATATGAACCTCGGGAAGTCCGAAAAGTGCTATTCGATGACTACGAGGTTCACTACGAACTCCGTGCCAATGACATCAAC
ATCGTGGATCTCTGGCATACAAAAGAAGAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8939.24 Da        Isoelectric Point: 6.7240

>AT45279 WP_025205703.1 NZ_CP006580:c4717525-4717277 [Enterobacter ludwigii]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAEHERRHQGIQAGLADVDAGRVVSHSDMVDFANRLK
KA

Download         Length: 249 bp

>AT45279 NZ_CP006580:c4717525-4717277 [Enterobacter ludwigii]
ATGGGGTCGCTTACTAAACAAACCATCAGTGCACAGATACCCGTTGAATTGGCTGCCGCTGTTGAGAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGCTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCTGAACATGAACGGCGTCATCAGGGTA
TTCAGGCCGGTCTTGCCGATGTGGATGCCGGTCGTGTGGTGAGTCATTCGGACATGGTGGATTTCGCTAACCGTTTAAAG
AAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References