Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 941450..942003 Replicon chromosome
Accession NZ_CP006580
Organism Enterobacter ludwigii strain P101

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag M942_RS04790 Protein ID WP_025203150.1
Coordinates 941689..942003 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag M942_RS04785 Protein ID WP_025203149.1
Coordinates 941450..941686 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M942_RS04745 936707..937186 + 480 WP_025203141.1 DNA repair protein RadC -
M942_RS04750 937201..937422 + 222 WP_025203142.1 DUF987 domain-containing protein -
M942_RS04755 937479..937805 + 327 WP_204247301.1 type IV toxin-antitoxin system YeeU family antitoxin -
M942_RS04760 937857..938234 + 378 WP_025203144.1 TA system toxin CbtA family protein -
M942_RS04765 938231..938722 + 492 WP_025203145.1 hypothetical protein -
M942_RS04770 938751..938963 + 213 WP_025203146.1 DUF957 domain-containing protein -
M942_RS04775 939073..940044 - 972 WP_025203147.1 glycosyltransferase -
M942_RS04780 940505..941338 + 834 WP_025203148.1 DUF4942 domain-containing protein -
M942_RS04785 941450..941686 + 237 WP_025203149.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M942_RS04790 941689..942003 + 315 WP_025203150.1 CcdB family protein Toxin
M942_RS04795 942287..944428 - 2142 WP_020883641.1 TonB-dependent siderophore receptor -
M942_RS04800 944813..945625 + 813 WP_014171637.1 ABC transporter ATP-binding protein -
M942_RS04805 945622..946605 + 984 WP_025203151.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 890313..946605 56292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11631.58 Da        Isoelectric Point: 8.0228

>T45265 WP_025203150.1 NZ_CP006580:941689-942003 [Enterobacter ludwigii]
MQFTVHINTGKSSTYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGGNRPERMIPLIRLTDGKEYAVMTHELASIPVRILG
VEFCSAAQYRTQIKAAIDFSFDGI

Download         Length: 315 bp

>T45265 NZ_CP006580:941689-942003 [Enterobacter ludwigii]
ATGCAATTCACCGTTCACATCAACACCGGGAAAAGCAGCACGTACCCTTTGTTGCTTGATGTCACGAGCGATATCATCGG
ACAGCTAAATCGCCGGATCGTGATACCTCTGCTACCGGTTGAAAAATATCCGGGTGGCAATCGCCCGGAAAGGATGATCC
CACTCATCAGACTAACCGATGGCAAGGAATACGCCGTCATGACCCACGAGCTGGCAAGTATTCCTGTTCGCATTCTGGGT
GTTGAGTTTTGCAGCGCGGCGCAATACCGGACACAGATAAAAGCGGCGATAGATTTTTCGTTTGACGGAATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8849.76 Da        Isoelectric Point: 6.8703

>AT45265 WP_025203149.1 NZ_CP006580:941450-941686 [Enterobacter ludwigii]
VAAKQRNTQSVTMTVERGLLSRAREAGINLSATLATALDAELRHQAARKWQEENRESLDALNRFHDEHGCFSDDHRTF

Download         Length: 237 bp

>AT45265 NZ_CP006580:941450-941686 [Enterobacter ludwigii]
GTGGCAGCAAAACAACGTAATACCCAAAGTGTCACAATGACTGTAGAGCGGGGTTTGCTCAGTCGGGCGCGTGAAGCCGG
TATTAACCTGAGCGCAACTCTGGCTACCGCCCTGGATGCTGAACTGCGCCATCAGGCTGCGAGAAAATGGCAGGAAGAAA
ACAGGGAGAGCCTCGACGCATTAAATCGTTTCCATGATGAACATGGTTGCTTCAGTGACGACCACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References