Detailed information of TA system TA045264

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 937479..938234
• Replicon: chromosome
• Accession: NZ_CP006580
• Organism: Enterobacter ludwigii strain P101

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: M942_RS04760
• Protein ID: WP_025203144.1
• Coordinates: 937857..938234 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: M942_RS04755
• Protein ID: WP_204247301.1
• Coordinates: 937479..937805 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M942_RS04710	932545..932778	-	234	WP_025203134.1	AlpA family transcriptional regulator	-
M942_RS04715	932900..933517	-	618	WP_025203135.1	inovirus Gp2 family protein	-
M942_RS04720	934512..934976	+	465	WP_025203136.1	hypothetical protein	-
M942_RS04725	935063..935425	+	363	WP_025203137.1	hypothetical protein	-
M942_RS04730	935503..935724	+	222	WP_025203138.1	hypothetical protein	-
M942_RS04735	935780..936013	+	234	WP_025203139.1	DUF905 family protein	-
M942_RS04740	936219..936695	+	477	WP_025203140.1	antirestriction protein	-
M942_RS04745	936707..937186	+	480	WP_025203141.1	DNA repair protein RadC	-
M942_RS04750	937201..937422	+	222	WP_025203142.1	DUF987 domain-containing protein	-
M942_RS04755	937479..937805	+	327	WP_204247301.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
M942_RS04760	937857..938234	+	378	WP_025203144.1	TA system toxin CbtA family protein	Toxin
M942_RS04765	938231..938722	+	492	WP_025203145.1	hypothetical protein	-
M942_RS04770	938751..938963	+	213	WP_025203146.1	DUF957 domain-containing protein	-
M942_RS04775	939073..940044	-	972	WP_025203147.1	glycosyltransferase	-
M942_RS04780	940505..941338	+	834	WP_025203148.1	DUF4942 domain-containing protein	-
M942_RS04785	941450..941686	+	237	WP_025203149.1	type II toxin-antitoxin system CcdA family antitoxin	-
M942_RS04790	941689..942003	+	315	WP_025203150.1	CcdB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	890313..946605	56292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14234.07 Da
• Isoelectric Point: 6.7261

>T45264 WP_025203144.1 NZ_CP006580:937857-938234 [Enterobacter ludwigii]
MQTQPLSSTREASPRPSPVEIWQQLLSHLLDRHYGLMLNDTPFGNDGVIQEHIDAGISLYDAVNFIVEKYDLIRTDRRGF
SAETQSPLITSIDILRARKATGLMTRNDYRTVTNITTGKYREVQP

Nucleotide

• Length: 378 bp

>T45264 NZ_CP006580:937857-938234 [Enterobacter ludwigii]
ATGCAAACCCAACCACTATCCTCAACGCGGGAGGCTTCGCCGCGACCGTCCCCCGTGGAGATCTGGCAGCAACTTCTGAG
CCACCTGCTGGATCGTCACTACGGTCTGATGCTCAACGACACGCCATTTGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTATACGATGCGGTGAATTTCATCGTGGAGAAATACGATCTGATTCGCACCGATCGCCGTGGTTTT
AGTGCAGAAACACAGTCACCGCTTATCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
CGATTACAGAACGGTGACCAACATCACCACCGGTAAATACCGCGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11893.71 Da
• Isoelectric Point: 6.4601

>AT45264 WP_204247301.1 NZ_CP006580:937479-937805 [Enterobacter ludwigii]
IAEPWWGLKCSITPCFGARLVQEGNRLHYLADRASITGTFSEADLRHLDQAFPVLLKQLELMLVSGELNPRHQHCVTLYA
KGLVCEADSLGSCGYVYIAIYPTPATTA

Nucleotide

• Length: 327 bp

>AT45264 NZ_CP006580:937479-937805 [Enterobacter ludwigii]
ATCGCCGAACCCTGGTGGGGGCTTAAATGCAGTATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCATTATCTTGCCGACCGCGCCAGCATCACAGGCACGTTCAGTGAGGCGGATTTGCGCCATCTCGACCAGGCGTTTCCGG
TGTTGCTCAAACAGCTTGAACTGATGCTTGTTTCCGGCGAACTCAATCCCCGCCATCAGCACTGTGTCACGCTTTACGCA
AAAGGGCTGGTATGCGAAGCCGACTCCCTCGGCAGTTGCGGTTATGTCTATATTGCGATTTATCCGACACCAGCCACAAC
CGCGTAA