Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 70445..70998 Replicon chromosome
Accession NZ_CP006580
Organism Enterobacter ludwigii strain P101

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag M942_RS00410 Protein ID WP_025202715.1
Coordinates 70684..70998 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag M942_RS00405 Protein ID WP_025202714.1
Coordinates 70445..70681 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M942_RS00365 65627..66106 + 480 WP_025202706.1 DNA repair protein RadC -
M942_RS00370 66118..66339 + 222 WP_025202707.1 DUF987 domain-containing protein -
M942_RS00375 66395..66721 + 327 WP_204247299.1 type IV toxin-antitoxin system YeeU family antitoxin -
M942_RS00380 66773..67150 + 378 WP_025202709.1 TA system toxin CbtA family protein -
M942_RS00385 67147..67638 + 492 WP_025202710.1 hypothetical protein -
M942_RS00390 67667..67879 + 213 WP_025202711.1 DUF957 domain-containing protein -
M942_RS00395 67999..68970 - 972 WP_025202712.1 glycosyltransferase -
M942_RS28025 69046..69210 - 165 WP_204247284.1 hypothetical protein -
M942_RS00400 69500..70333 + 834 WP_025202713.1 DUF4942 domain-containing protein -
M942_RS00405 70445..70681 + 237 WP_025202714.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M942_RS00410 70684..70998 + 315 WP_025202715.1 CcdB family protein Toxin
M942_RS00415 71275..72612 - 1338 WP_025202716.1 adenine permease AdeP -
M942_RS00420 72779..73444 + 666 WP_025202717.1 6-phosphogluconate phosphatase -
M942_RS00425 73530..74255 - 726 WP_008500182.1 phosphate signaling complex protein PhoU -
M942_RS00430 74270..75043 - 774 WP_014172291.1 phosphate ABC transporter ATP-binding protein PstB -
M942_RS00435 75091..75981 - 891 WP_025202718.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11753.80 Da        Isoelectric Point: 8.9345

>T45263 WP_025202715.1 NZ_CP006580:70684-70998 [Enterobacter ludwigii]
MQFTVHINTGKNSTYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGGNRPERMIPLIRLTDGKEYAVMTHELASIPVRILG
VEFCRAAQYRTQIKAAIDFLFDGI

Download         Length: 315 bp

>T45263 NZ_CP006580:70684-70998 [Enterobacter ludwigii]
ATGCAGTTCACCGTTCACATCAACACCGGGAAAAACAGCACGTACCCTTTGTTGCTTGATGTCACGAGCGATATCATCGG
ACAGCTAAATCGCCGGATCGTGATACCTCTGCTACCGGTTGAAAAATATCCGGGTGGCAATCGCCCGGAAAGGATGATCC
CACTCATCAGACTAACCGATGGCAAGGAATACGCCGTCATGACCCACGAGCTGGCAAGTATTCCTGTTCGCATTCTGGGT
GTTGAGTTTTGCCGCGCGGCGCAATACCGGACACAGATAAAAGCGGCGATAGATTTTTTGTTTGACGGAATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8800.73 Da        Isoelectric Point: 5.6713

>AT45263 WP_025202714.1 NZ_CP006580:70445-70681 [Enterobacter ludwigii]
VAAKQRNTQSVTMTVERGLLSRAREAGINLSATLATALDAELRYQAARKWQEENMESLDALNRFHDEHGCFSDDSRTF

Download         Length: 237 bp

>AT45263 NZ_CP006580:70445-70681 [Enterobacter ludwigii]
GTGGCAGCAAAACAACGCAATACCCAAAGTGTCACAATGACCGTAGAACGGGGTTTGCTCAGTCGGGCCCGTGAAGCAGG
CATTAACCTGAGCGCAACTCTGGCTACCGCTCTGGATGCTGAACTGCGCTATCAGGCTGCGAGAAAATGGCAGGAAGAGA
ATATGGAGAGTCTCGACGCGTTAAATCGTTTCCATGATGAACATGGTTGCTTCAGCGACGACTCCAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References