Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB-PIN
Location 2262012..2262640 Replicon chromosome
Accession NZ_CP006577
Organism Archaeoglobus fulgidus DSM 8774

Toxin (Protein)


Gene name vapC Uniprot ID O30310
Locus tag AFULGI_RS12710 Protein ID WP_010879846.1
Coordinates 2262236..2262640 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O30311
Locus tag AFULGI_RS12705 Protein ID WP_010879845.1
Coordinates 2262012..2262239 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFULGI_RS12675 (AFULGI_00026320) 2257079..2257525 + 447 WP_010879821.1 flavodoxin family protein -
AFULGI_RS12680 (AFULGI_00026330) 2257518..2258636 - 1119 WP_048064561.1 aconitase X -
AFULGI_RS12685 (AFULGI_00026340) 2258627..2259436 - 810 WP_010879823.1 spermidine synthase -
AFULGI_RS12690 (AFULGI_00026350) 2259470..2259982 + 513 WP_048096389.1 hydrolase -
AFULGI_RS12695 (AFULGI_00026360) 2259983..2260726 - 744 WP_010879825.1 alpha/beta hydrolase -
AFULGI_RS13950 2260735..2261133 - 399 Protein_2570 hypothetical protein -
AFULGI_RS13955 2261655..2261867 - 213 Protein_2571 transposase -
AFULGI_RS12705 (AFULGI_00026390) 2262012..2262239 + 228 WP_010879845.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AFULGI_RS12710 (AFULGI_00026400) 2262236..2262640 + 405 WP_010879846.1 PIN domain-containing protein Toxin
AFULGI_RS12715 (AFULGI_00026410) 2262657..2263532 - 876 WP_010879847.1 MBL fold metallo-hydrolase -
AFULGI_RS12720 (AFULGI_00026420) 2263585..2264070 + 486 WP_010879848.1 hypothetical protein -
AFULGI_RS12725 (AFULGI_00026430) 2264112..2265434 - 1323 WP_010879849.1 AIR synthase-related protein -
AFULGI_RS12730 (AFULGI_00026440) 2265537..2266301 + 765 WP_010879850.1 ABC transporter ATP-binding protein -
AFULGI_RS12735 (AFULGI_00026450) 2266271..2267368 + 1098 WP_048096393.1 SufD family Fe-S cluster assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(3-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15519.06 Da        Isoelectric Point: 6.7318

>T45261 WP_010879846.1 NZ_CP006577:2262236-2262640 [Archaeoglobus fulgidus DSM 8774]
MKAVIDTNVIVYDTFEDSVFHQEAMQLLDRIDVWVIPTIVIHEYVWVLKSLKVDVKEIKYKVEEYLNHYKTKMVSENKQI
VLSALERIVGGGLSLSRYNDELILAVAGREKISLATFDERLRRQARARGVEVIP

Download         Length: 405 bp

>T45261 NZ_CP006577:2262236-2262640 [Archaeoglobus fulgidus DSM 8774]
ATGAAAGCCGTCATAGATACAAATGTTATAGTCTACGACACCTTTGAAGACAGCGTTTTTCATCAGGAAGCCATGCAACT
CCTCGATAGAATTGATGTGTGGGTAATCCCTACGATAGTTATTCACGAGTATGTTTGGGTCCTCAAATCACTGAAGGTGG
ACGTGAAAGAAATCAAATACAAAGTGGAGGAGTATCTTAACCACTATAAAACGAAAATGGTTTCAGAAAATAAGCAAATC
GTTTTGTCAGCACTGGAAAGAATTGTAGGTGGGGGATTAAGCCTTTCAAGGTACAACGACGAGTTGATACTTGCTGTTGC
TGGTAGGGAAAAAATAAGCCTTGCAACCTTCGACGAGAGGTTGAGAAGGCAGGCGAGAGCAAGAGGTGTAGAAGTAATTC
CATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8464.94 Da        Isoelectric Point: 10.0936

>AT45261 WP_010879845.1 NZ_CP006577:2262012-2262239 [Archaeoglobus fulgidus DSM 8774]
MKVKVTRNFQITIPAEVRRKMGLKLGDVLEVEYNEEKGEAIIRKLGGERRKLKAGRKLTPDEIEALIAEGMGDNL

Download         Length: 228 bp

>AT45261 NZ_CP006577:2262012-2262239 [Archaeoglobus fulgidus DSM 8774]
ATGAAAGTAAAAGTTACTAGGAATTTTCAGATTACTATACCTGCCGAAGTTAGGAGAAAGATGGGATTAAAGCTGGGCGA
TGTGCTTGAAGTTGAATACAACGAGGAGAAGGGAGAGGCCATTATAAGGAAGCTCGGTGGAGAGAGAAGGAAGCTGAAAG
CGGGAAGAAAGCTTACGCCGGACGAGATAGAGGCGCTGATAGCTGAGGGAATGGGCGATAACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075WJC8

Antitoxin

Source ID Structure
AlphaFold DB A0A075WP36

References