Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 56881..57521 Replicon chromosome
Accession NZ_CP006577
Organism Archaeoglobus fulgidus DSM 8774

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AFULGI_RS00275 Protein ID WP_010877579.1
Coordinates 56881..57294 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A075W906
Locus tag AFULGI_RS13005 Protein ID WP_052270455.1
Coordinates 57291..57521 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFULGI_RS00230 (AFULGI_00000480) 52578..52976 - 399 WP_010877569.1 DUF126 domain-containing protein -
AFULGI_RS00235 (AFULGI_00000490) 52997..53137 - 141 WP_010877570.1 DNA-directed RNA polymerase subunit P -
AFULGI_RS00240 (AFULGI_00000500) 53141..53392 - 252 WP_010877571.1 50S ribosomal protein L37Ae -
AFULGI_RS00245 (AFULGI_00000510) 53431..53955 - 525 WP_048094782.1 PUA domain-containing protein -
AFULGI_RS00250 (AFULGI_00000520) 53922..54326 - 405 WP_048094785.1 hypothetical protein -
AFULGI_RS00255 (AFULGI_00000530) 54424..54705 + 282 WP_010877574.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
AFULGI_RS00260 (AFULGI_00000540) 54705..55295 + 591 WP_048094788.1 dTMP kinase -
AFULGI_RS00265 (AFULGI_00000550) 55269..56108 - 840 WP_048064160.1 CBS domain-containing protein -
AFULGI_RS13275 56212..56505 - 294 Protein_55 hypothetical protein -
AFULGI_RS13575 (AFULGI_00000570) 56632..56787 - 156 WP_156029468.1 hypothetical protein -
AFULGI_RS00275 (AFULGI_00000580) 56881..57294 - 414 WP_010877579.1 type II toxin-antitoxin system VapC family toxin Toxin
AFULGI_RS13005 (AFULGI_00000590) 57291..57521 - 231 WP_052270455.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AFULGI_RS00285 (AFULGI_00000600) 57605..58291 - 687 WP_010877581.1 CRISPR-associated protein Cas5 -
AFULGI_RS00290 (AFULGI_00000610) 58303..59256 - 954 WP_010877582.1 DevR family CRISPR-associated autoregulator -
AFULGI_RS00295 (AFULGI_00000620) 59257..59619 - 363 WP_010877583.1 hypothetical protein -
AFULGI_RS00300 (AFULGI_00000630) 59606..60658 - 1053 WP_231487532.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-126)

Antitoxin

(6-45)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 16415.97 Da        Isoelectric Point: 4.5216

>T45260 WP_010877579.1 NZ_CP006577:c57294-56881 [Archaeoglobus fulgidus DSM 8774]
MKIFLDANYLIYLKYSESDEIFDYCVNLLRKIEKYDLVTNMLAIDEVIWILNRKYKIELDEVFEYLDRLLSFLRVVPIEA
EDYDLMKEFMLGYNLKPSDSLHLSSMRRHGVSVIVSEDSDFDRVDWVKRVWIGRGDV

Download         Length: 414 bp

>T45260 NZ_CP006577:c57294-56881 [Archaeoglobus fulgidus DSM 8774]
ATGAAAATTTTTCTGGATGCCAATTATCTGATTTACCTGAAGTACTCTGAAAGTGACGAAATCTTTGATTACTGCGTAAA
CCTTCTCAGAAAAATTGAAAAATACGACCTGGTGACTAACATGCTCGCAATCGATGAGGTTATCTGGATACTCAACAGAA
AGTATAAAATCGAGCTTGATGAGGTGTTTGAGTATCTTGACAGACTTTTAAGCTTTCTCAGGGTTGTTCCGATTGAAGCT
GAGGATTACGACCTCATGAAGGAGTTCATGCTTGGATACAACCTCAAACCCTCGGACTCTCTGCATCTTTCGAGCATGAG
GAGACATGGGGTGAGTGTGATAGTCTCGGAGGATTCCGACTTTGACAGGGTGGATTGGGTTAAGAGGGTGTGGATTGGCA
GAGGTGATGTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8649.22 Da        Isoelectric Point: 6.3756

>AT45260 WP_052270455.1 NZ_CP006577:c57521-57291 [Archaeoglobus fulgidus DSM 8774]
MVKLKVKVGAKGQVVIPKVIRDKLGIKPDDVLLVDEEGGKIVIEKQDIDDFIEWVKKTRKKVAGEVYRIALEDEFE

Download         Length: 231 bp

>AT45260 NZ_CP006577:c57521-57291 [Archaeoglobus fulgidus DSM 8774]
ATGGTAAAACTCAAGGTTAAAGTAGGTGCGAAGGGGCAGGTCGTGATTCCAAAGGTTATAAGGGACAAGCTGGGAATAAA
GCCAGATGATGTCCTTCTTGTGGATGAAGAGGGCGGGAAGATAGTGATTGAAAAGCAGGACATCGATGATTTCATTGAGT
GGGTCAAAAAAACCAGAAAGAAGGTTGCGGGCGAGGTTTACAGAATTGCATTGGAGGATGAGTTCGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A075W906

References