Detailed information of TA system TA045257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3414223..3414832
• Replicon: chromosome
• Accession: NZ_CP006569
• Organism: Sodalis praecaptivus strain HS1

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: W0HVX7
• Locus tag: SANT_RS15245
• Protein ID: WP_011410544.1
• Coordinates: 3414629..3414832 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: W0I0J8
• Locus tag: SANT_RS15240
• Protein ID: WP_025246875.1
• Coordinates: 3414223..3414582 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANT_RS15225	3409962..3413126	+	3165	WP_025423132.1	multidrug efflux RND transporter permease subunit	-
SANT_RS15230	3413278..3413535	+	258	WP_025246874.1	type B 50S ribosomal protein L31	-
SANT_RS15235	3413556..3413696	+	141	WP_025423133.1	type B 50S ribosomal protein L36	-
SANT_RS15240	3414223..3414582	+	360	WP_025246875.1	Hha toxicity modulator TomB	Antitoxin
SANT_RS15245	3414629..3414832	+	204	WP_011410544.1	hemolysin expression modulator Hha	Toxin
SANT_RS15250	3415623..3415952	+	330	WP_025423134.1	MGMT family protein	-
SANT_RS15255	3416581..3417138	-	558	WP_025423135.1	YbaY family lipoprotein	-
SANT_RS15260	3417400..3418686	-	1287	WP_025423136.1	ammonium transporter AmtB	-
SANT_RS15265	3418723..3419061	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8150.53 Da
• Isoelectric Point: 8.8913

>T45257 WP_011410544.1 NZ_CP006569:3414629-3414832 [Sodalis praecaptivus]
MKKIDYLMRLRKCRTLETLERVIEKNKYELSDDELEIFNSAADHRLAELTMNKLYDKVPVSVWKYVR

Nucleotide

• Length: 204 bp

>T45257 NZ_CP006569:3414629-3414832 [Sodalis praecaptivus]
ATGAAAAAGATCGACTATTTAATGCGCTTGAGGAAGTGCCGAACGCTGGAAACCCTCGAGCGTGTGATTGAAAAAAACAA
ATATGAACTGTCTGATGACGAACTGGAGATATTCAATTCCGCCGCCGATCATCGCCTGGCGGAACTGACCATGAACAAGC
TGTACGACAAAGTTCCAGTTTCTGTCTGGAAGTATGTACGCTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13973.50 Da
• Isoelectric Point: 4.4687

>AT45257 WP_025246875.1 NZ_CP006569:3414223-3414582 [Sodalis praecaptivus]
MDEYSPKRYDIAQLKYLCENLYDEGIASLGDSYHGWVNDPSSAVNLQLNELIEHIAANIVIFKLKYHNESELTDQVETFL
DDTFTLFSSYGINNYDIQRWRRSRRRLFGTFSETELCTT

Nucleotide

• Length: 360 bp

>AT45257 NZ_CP006569:3414223-3414582 [Sodalis praecaptivus]
ATGGATGAGTATTCACCCAAACGCTACGATATTGCGCAATTGAAATACCTGTGTGAAAATCTCTATGATGAAGGCATTGC
CAGTCTGGGTGACAGCTATCATGGTTGGGTAAATGACCCAAGTTCCGCCGTCAATTTGCAGCTTAACGAATTAATTGAGC
ACATAGCGGCGAATATTGTCATCTTCAAACTTAAATACCATAATGAAAGTGAGCTTACCGATCAGGTTGAAACCTTTTTA
GACGATACTTTTACCCTGTTCAGTAGCTATGGCATCAATAATTACGATATCCAGCGCTGGCGTCGCAGCCGCAGGCGTTT
ATTCGGAACATTCTCGGAGACAGAGCTCTGTACAACCTGA

Structures

Toxin

• AlphaFold DB: W0HVX7

Antitoxin

• AlphaFold DB: W0I0J8