Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 3351650..3352285 | Replicon | chromosome |
| Accession | NZ_CP006569 | ||
| Organism | Sodalis praecaptivus strain HS1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | W0I0F6 |
| Locus tag | SANT_RS14875 | Protein ID | WP_025423067.1 |
| Coordinates | 3352109..3352285 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | W0HZI4 |
| Locus tag | SANT_RS14870 | Protein ID | WP_025423066.1 |
| Coordinates | 3351650..3352060 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SANT_RS14825 | 3347489..3348007 | - | 519 | WP_025423058.1 | terminase small subunit | - |
| SANT_RS14830 | 3348171..3348698 | - | 528 | WP_025423059.1 | Rha family transcriptional regulator | - |
| SANT_RS14835 | 3349325..3349591 | - | 267 | WP_025423060.1 | hypothetical protein | - |
| SANT_RS14845 | 3349733..3349978 | - | 246 | WP_051440240.1 | hypothetical protein | - |
| SANT_RS14850 | 3350026..3350376 | - | 351 | WP_025423062.1 | hypothetical protein | - |
| SANT_RS14855 | 3350373..3350840 | - | 468 | WP_025423063.1 | glycoside hydrolase family protein | - |
| SANT_RS14860 | 3350837..3351100 | - | 264 | WP_025423064.1 | hypothetical protein | - |
| SANT_RS23870 | 3351097..3351504 | - | 408 | WP_148296303.1 | hypothetical protein | - |
| SANT_RS14870 | 3351650..3352060 | - | 411 | WP_025423066.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| SANT_RS14875 | 3352109..3352285 | - | 177 | WP_025423067.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| SANT_RS14880 | 3352480..3353280 | - | 801 | WP_200867250.1 | phage antirepressor KilAC domain-containing protein | - |
| SANT_RS14885 | 3353292..3353840 | - | 549 | WP_038668639.1 | Bro-N domain-containing protein | - |
| SANT_RS22995 | 3353869..3354501 | - | 633 | WP_051440179.1 | HNH endonuclease | - |
| SANT_RS14895 | 3354596..3354991 | + | 396 | WP_038668642.1 | helix-turn-helix domain-containing protein | - |
| SANT_RS14900 | 3354999..3355388 | - | 390 | WP_025423072.1 | antitermination protein | - |
| SANT_RS14905 | 3355385..3355981 | - | 597 | WP_025423073.1 | recombination protein NinG | - |
| SANT_RS14910 | 3356144..3356479 | - | 336 | WP_025423074.1 | hypothetical protein | - |
| SANT_RS14915 | 3356489..3356938 | - | 450 | WP_025423075.1 | DUF1367 family protein | - |
| SANT_RS14920 | 3356954..3357241 | - | 288 | WP_025423076.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3300574..3373560 | 72986 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6548.71 Da Isoelectric Point: 11.4650
>T45256 WP_025423067.1 NZ_CP006569:c3352285-3352109 [Sodalis praecaptivus]
VKQSEFRRWLESQGVEVSNGTNHLKLKLGGKRSVMPRHPGAEIKEALRKAILKQLGLK
VKQSEFRRWLESQGVEVSNGTNHLKLKLGGKRSVMPRHPGAEIKEALRKAILKQLGLK
Download Length: 177 bp
>T45256 NZ_CP006569:c3352285-3352109 [Sodalis praecaptivus]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGGGTAGAGGTTTCAAACGGCACAAACCATTTGAAGCTCAA
ACTAGGCGGGAAGCGAAGCGTAATGCCGAGGCATCCCGGAGCTGAGATAAAAGAAGCGCTGCGAAAGGCCATACTTAAGC
AGCTTGGCCTGAAATAA
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGGGTAGAGGTTTCAAACGGCACAAACCATTTGAAGCTCAA
ACTAGGCGGGAAGCGAAGCGTAATGCCGAGGCATCCCGGAGCTGAGATAAAAGAAGCGCTGCGAAAGGCCATACTTAAGC
AGCTTGGCCTGAAATAA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14960.10 Da Isoelectric Point: 4.4840
>AT45256 WP_025423066.1 NZ_CP006569:c3352060-3351650 [Sodalis praecaptivus]
MRYPVNIEPCDEGGFFVSFPDIPEALTQGDTREEALAMGLDGLVTSFDFYFEDNRKVPPPGVITGDYVDVPLSVASKVVL
LNAFVDSGLTQVELASRMGVKKQEVTRLFDLHHSTKIDTVQRAMVALGKRLELQAA
MRYPVNIEPCDEGGFFVSFPDIPEALTQGDTREEALAMGLDGLVTSFDFYFEDNRKVPPPGVITGDYVDVPLSVASKVVL
LNAFVDSGLTQVELASRMGVKKQEVTRLFDLHHSTKIDTVQRAMVALGKRLELQAA
Download Length: 411 bp
>AT45256 NZ_CP006569:c3352060-3351650 [Sodalis praecaptivus]
ATGCGATATCCCGTTAATATTGAGCCGTGCGATGAGGGGGGATTTTTTGTCTCGTTCCCCGATATCCCGGAGGCGCTTAC
CCAGGGCGATACGCGAGAGGAAGCATTGGCGATGGGGCTCGATGGGTTGGTTACCTCGTTTGATTTTTACTTTGAGGATA
ATCGTAAAGTCCCACCGCCCGGCGTCATCACTGGCGATTATGTAGACGTCCCGCTTAGCGTCGCTTCAAAAGTGGTGCTG
CTTAATGCGTTTGTTGATTCCGGCTTAACCCAGGTTGAGCTGGCGTCGCGCATGGGAGTAAAAAAACAGGAGGTAACACG
CCTGTTTGACCTGCATCACTCAACAAAAATAGATACAGTGCAGCGCGCTATGGTGGCGCTCGGAAAGCGGCTAGAACTAC
AAGCTGCATAA
ATGCGATATCCCGTTAATATTGAGCCGTGCGATGAGGGGGGATTTTTTGTCTCGTTCCCCGATATCCCGGAGGCGCTTAC
CCAGGGCGATACGCGAGAGGAAGCATTGGCGATGGGGCTCGATGGGTTGGTTACCTCGTTTGATTTTTACTTTGAGGATA
ATCGTAAAGTCCCACCGCCCGGCGTCATCACTGGCGATTATGTAGACGTCCCGCTTAGCGTCGCTTCAAAAGTGGTGCTG
CTTAATGCGTTTGTTGATTCCGGCTTAACCCAGGTTGAGCTGGCGTCGCGCATGGGAGTAAAAAAACAGGAGGTAACACG
CCTGTTTGACCTGCATCACTCAACAAAAATAGATACAGTGCAGCGCGCTATGGTGGCGCTCGGAAAGCGGCTAGAACTAC
AAGCTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|