Detailed information of TA system TA045244

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 867844..868498
• Replicon: chromosome
• Accession: NZ_CP006569
• Organism: Sodalis praecaptivus strain HS1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W0HPU4
• Locus tag: SANT_RS03950
• Protein ID: WP_025421004.1
• Coordinates: 868091..868498 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W0HUI9
• Locus tag: SANT_RS03945
• Protein ID: WP_025246815.1
• Coordinates: 867844..868110 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANT_RS03930	865066..865674	-	609	WP_025421001.1	HD domain-containing protein	-
SANT_RS03935	865884..866534	+	651	WP_025421002.1	hemolysin III family protein	-
SANT_RS03940	866645..867631	-	987	WP_025421003.1	tRNA-modifying protein YgfZ	-
SANT_RS03945	867844..868110	+	267	WP_025246815.1	FAD assembly factor SdhE	Antitoxin
SANT_RS03950	868091..868498	+	408	WP_025421004.1	protein YgfX	Toxin
SANT_RS03955	868538..869056	-	519	WP_025421005.1	flavodoxin FldB	-
SANT_RS03960	869158..870057	+	900	WP_025421006.1	site-specific tyrosine recombinase XerD	-
SANT_RS03965	870133..870849	+	717	WP_025421007.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
SANT_RS03970	870857..872593	+	1737	WP_025421008.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15912.86 Da
• Isoelectric Point: 11.2555

>T45244 WP_025421004.1 NZ_CP006569:868091-868498 [Sodalis praecaptivus]
VALWRCDIRVSWRTQLCSLAFYGILIMLILLSPWPENYGLVWLTLVLVVVFECIRSQRNIMSCRGELVLMSDSSIQWHRE
EWTFTRKAWMLKGGVLLSLRKAGGTRRRRLWLAADSMDGREFRHLRQLLARQTGF

Nucleotide

• Length: 408 bp

>T45244 NZ_CP006569:868091-868498 [Sodalis praecaptivus]
GTGGCCCTTTGGCGATGTGATATTCGGGTCTCTTGGCGCACTCAGCTTTGCTCGCTGGCGTTTTACGGGATCCTGATAAT
GCTGATTCTGCTTTCTCCCTGGCCGGAGAATTACGGGCTGGTGTGGTTGACGTTAGTGCTGGTAGTGGTGTTTGAGTGCA
TCCGCAGCCAGCGCAATATCATGTCCTGCCGTGGCGAGCTGGTGCTGATGAGCGACAGCAGTATTCAATGGCATCGCGAG
GAGTGGACCTTTACCCGCAAAGCCTGGATGCTCAAGGGCGGCGTATTGCTCAGCCTGCGTAAAGCCGGCGGCACGCGGCG
CCGGCGTCTGTGGCTGGCGGCGGACAGCATGGACGGCCGGGAATTCCGCCACCTGCGCCAGCTGCTGGCGCGACAGACCG
GGTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10535.07 Da
• Isoelectric Point: 5.1099

>AT45244 WP_025246815.1 NZ_CP006569:867844-868110 [Sodalis praecaptivus]
MDITNKARIHWACRRGMRELDIAIMPFFEQDFDALDDQDKRRFVRLLECDDPDLFNWLMNHGQPDDRELQQIISMIQTRN
KARGPLAM

Nucleotide

• Length: 267 bp

>AT45244 NZ_CP006569:867844-868110 [Sodalis praecaptivus]
ATGGATATCACCAATAAAGCGCGGATCCATTGGGCCTGCCGACGCGGCATGCGCGAGCTGGATATCGCCATTATGCCGTT
CTTTGAACAGGATTTTGACGCTCTGGATGACCAGGACAAGCGGCGCTTTGTCCGGCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGTTGATGAATCACGGCCAGCCTGACGATCGCGAATTGCAGCAAATTATCTCAATGATACAAACGCGAAAC
AAAGCCCGTGGCCCTTTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: W0HPU4

Antitoxin

• AlphaFold DB: W0HUI9