Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4327980..4328589 Replicon chromosome
Accession NZ_CP006568
Organism Candidatus Sodalis pierantonius str. SOPE

Toxin (Protein)


Gene name Hha Uniprot ID W0HVX7
Locus tag SOPEG_RS21425 Protein ID WP_011410544.1
Coordinates 4328386..4328589 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0I0J8
Locus tag SOPEG_RS21420 Protein ID WP_025246875.1
Coordinates 4327980..4328339 (+) Length 120 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SOPEG_RS21410 4323724..4326888 + 3165 WP_025246873.1 multidrug efflux RND transporter permease subunit -
SOPEG_RS21415 4327040..4327297 + 258 WP_025246874.1 type B 50S ribosomal protein L31 -
SOPEG_RS25645 4327318..4327458 + 141 WP_071882278.1 type B 50S ribosomal protein L36 -
SOPEG_RS21420 4327980..4328339 + 360 WP_025246875.1 Hha toxicity modulator TomB Antitoxin
SOPEG_RS21425 4328386..4328589 + 204 WP_011410544.1 hemolysin expression modulator Hha Toxin
SOPEG_RS21430 4329383..4329712 + 330 WP_025246876.1 MGMT family protein -
SOPEG_RS21435 4330033..4330593 - 561 WP_025246877.1 YbaY family lipoprotein -
SOPEG_RS21440 4330616..4331212 - 597 Protein_4339 IS256 family transposase -
SOPEG_RS21450 4331285..4332492 + 1208 Protein_4340 IS256 family transposase -
SOPEG_RS26830 4332526..4333147 - 622 Protein_4341 IS256-like element ISSoEn2 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8150.53 Da        Isoelectric Point: 8.8913

>T45243 WP_011410544.1 NZ_CP006568:4328386-4328589 [Candidatus Sodalis pierantonius str. SOPE]
MKKIDYLMRLRKCRTLETLERVIEKNKYELSDDELEIFNSAADHRLAELTMNKLYDKVPVSVWKYVR

Download         Length: 204 bp

>T45243 NZ_CP006568:4328386-4328589 [Candidatus Sodalis pierantonius str. SOPE]
ATGAAAAAGATCGACTATTTAATGCGCTTGAGGAAGTGCCGAACGCTGGAAACCCTCGAGCGTGTGATTGAAAAAAACAA
ATATGAACTGTCTGATGATGAACTGGAGATATTCAATTCCGCCGCCGATCATCGCCTGGCGGAACTGACCATGAACAAGC
TGTACGACAAAGTTCCAGTTTCTGTCTGGAAGTATGTACGCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13973.50 Da        Isoelectric Point: 4.4687

>AT45243 WP_025246875.1 NZ_CP006568:4327980-4328339 [Candidatus Sodalis pierantonius str. SOPE]
MDEYSPKRYDIAQLKYLCENLYDEGIASLGDSYHGWVNDPSSAVNLQLNELIEHIAANIVIFKLKYHNESELTDQVETFL
DDTFTLFSSYGINNYDIQRWRRSRRRLFGTFSETELCTT

Download         Length: 360 bp

>AT45243 NZ_CP006568:4327980-4328339 [Candidatus Sodalis pierantonius str. SOPE]
ATGGATGAGTATTCACCCAAACGCTACGATATTGCGCAATTGAAATACCTGTGTGAAAATCTCTATGATGAAGGCATTGC
CAGTCTGGGTGACAGCTATCATGGTTGGGTAAATGACCCAAGTTCCGCCGTCAATTTGCAGCTTAACGAATTAATTGAGC
ACATAGCGGCGAATATTGTCATCTTCAAACTTAAATACCATAATGAAAGTGAGCTTACCGATCAGGTTGAAACCTTTTTA
GACGATACTTTTACCCTGTTCAGTAGCTATGGCATCAATAATTACGATATCCAGCGCTGGCGTCGCAGCCGCAGGCGTTT
ATTCGGAACATTCTCGGAGACAGAGCTCTGTACAACCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB W0HVX7


Antitoxin

Source ID Structure
AlphaFold DB W0I0J8

References