Detailed information of TA system TA045242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2029618..2030128
• Replicon: chromosome
• Accession: NZ_CP006471
• Organism: Synechococcus sp. UTEX 2973

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q8KPS4
• Locus tag: M744_RS10110
• Protein ID: WP_011242657.1
• Coordinates: 2029865..2030128 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q31NY1
• Locus tag: M744_RS10105
• Protein ID: WP_011242656.1
• Coordinates: 2029618..2029872 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M744_RS10065	2025913..2026920	-	1008	WP_011377920.1	acyl-CoA dehydrogenase family protein	-
M744_RS10070	2026946..2027428	-	483	WP_173282542.1	glutathione peroxidase	-
M744_RS10075	2027580..2027996	-	417	WP_011377919.1	type II toxin-antitoxin system VapC family toxin	-
M744_RS10080	2028000..2028224	-	225	WP_039755738.1	hypothetical protein	-
M744_RS10085	2028376..2028636	+	261	WP_011242652.1	DUF4160 domain-containing protein	-
M744_RS10090	2028641..2028985	+	345	WP_011242653.1	DUF2442 domain-containing protein	-
M744_RS10095	2028985..2029233	+	249	WP_011377918.1	DUF4160 domain-containing protein	-
M744_RS10100	2029236..2029496	+	261	WP_011242655.1	DUF2442 domain-containing protein	-
M744_RS10105	2029618..2029872	+	255	WP_011242656.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
M744_RS10110	2029865..2030128	+	264	WP_011242657.1	Txe/YoeB family addiction module toxin	Toxin
M744_RS10115	2030255..2030530	-	276	WP_011242658.1	DUF2281 domain-containing protein	-
M744_RS10120	2030527..2030691	-	165	WP_011377917.1	tyrosine-type recombinase/integrase	-
M744_RS10125	2030764..2031006	+	243	WP_190528567.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
M744_RS10130	2031003..2031416	+	414	WP_011242660.1	type II toxin-antitoxin system VapC family toxin	-
M744_RS10135	2031504..2033954	+	2451	WP_011242661.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10434.75 Da
• Isoelectric Point: 6.9760

>T45242 WP_011242657.1 NZ_CP006471:2029865-2030128 [Synechococcus sp. UTEX 2973]
MRKLAWTNEAWEDYLYWQGQDKKTLNRINKLITETLRSPFEGIGKPEALRENLTGFWSRRIDDTNRLVYAVADDYLTIIS
CRYHYSD

Nucleotide

• Length: 264 bp

>T45242 NZ_CP006471:2029865-2030128 [Synechococcus sp. UTEX 2973]
ATGCGTAAGCTGGCTTGGACAAACGAGGCTTGGGAAGATTACCTGTATTGGCAAGGGCAGGACAAGAAGACCTTAAATCG
CATCAACAAGCTCATTACCGAAACCTTGCGATCGCCCTTTGAGGGGATTGGTAAGCCAGAAGCGCTCAGGGAGAACCTGA
CTGGGTTTTGGTCACGCCGCATTGACGACACCAATCGCTTAGTTTACGCAGTAGCAGATGACTACCTGACCATTATTTCC
TGTCGCTACCACTACAGCGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.72 Da
• Isoelectric Point: 5.6400

>AT45242 WP_011242656.1 NZ_CP006471:2029618-2029872 [Synechococcus sp. UTEX 2973]
MKVVSFSDARKNLKTVLDEVVNDADYTIITRRNAEEVVVMSLDSFNSLIETFHLLKSPANAAHLQRSIAQYQQGQTVERN
LLDA

Nucleotide

• Length: 255 bp

>AT45242 NZ_CP006471:2029618-2029872 [Synechococcus sp. UTEX 2973]
ATGAAAGTTGTTTCCTTCAGTGACGCCAGAAAAAATCTCAAGACTGTCTTGGATGAAGTCGTCAACGACGCTGACTACAC
GATCATTACTCGCCGCAATGCCGAGGAAGTCGTGGTCATGTCCCTCGACTCCTTCAATAGCCTGATCGAAACCTTCCACC
TGCTCAAATCCCCTGCCAATGCTGCTCACCTACAACGCTCGATCGCTCAGTACCAGCAAGGTCAAACAGTCGAGCGAAAT
CTATTAGATGCGTAA

Structures

Toxin

• AlphaFold DB: Q8KPS4

Antitoxin

• AlphaFold DB: Q31NY1