Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 28332..28924 Replicon plasmid pAU20d
Accession NZ_CP006371
Organism Aureimonas sp. AU20

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M673_RS23885 Protein ID WP_082640092.1
Coordinates 28332..28601 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M673_RS22570 Protein ID WP_187301372.1
Coordinates 28604..28924 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M673_RS22545 23524..24180 - 657 WP_061978997.1 SOS response-associated peptidase -
M673_RS22550 24424..25176 + 753 WP_082640091.1 thermonuclease family protein -
M673_RS22555 25188..26195 - 1008 WP_061978998.1 hypothetical protein -
M673_RS22560 27232..27480 + 249 WP_148640235.1 hypothetical protein -
M673_RS24755 28098..28238 - 141 WP_156421150.1 hypothetical protein -
M673_RS23885 28332..28601 + 270 WP_082640092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M673_RS22570 28604..28924 + 321 WP_187301372.1 putative addiction module antidote protein Antitoxin
M673_RS22575 28931..29620 - 690 WP_148640236.1 DUF2726 domain-containing protein -
M673_RS24760 29869..30030 + 162 WP_156421149.1 hypothetical protein -
M673_RS22580 30754..31299 - 546 WP_061979002.1 PAS domain-containing protein -
M673_RS22585 31473..31838 + 366 WP_061979003.1 helix-turn-helix domain-containing protein -
M673_RS22590 32374..32859 + 486 WP_148640242.1 molybdopterin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101355 101355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(7-88)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10110.34 Da        Isoelectric Point: 6.4610

>T45241 WP_082640092.1 NZ_CP006371:28332-28601 [Aureimonas sp. AU20]
MDVACWDLRDRQARSRIQIRLDHIEEGGFGDHKSVGDGVSELRFDFGPGYRVYYTQRGNVIVILLWGGDKSTQQGDIRKA
KKLAADLED

Download         Length: 270 bp

>T45241 NZ_CP006371:28332-28601 [Aureimonas sp. AU20]
CTGGATGTTGCGTGCTGGGATCTGCGAGATCGGCAAGCGCGATCCCGTATCCAGATCCGCCTCGATCATATCGAGGAAGG
CGGGTTCGGCGATCATAAAAGCGTTGGAGACGGCGTTTCGGAACTCCGCTTCGACTTCGGTCCCGGATACCGTGTCTACT
ATACTCAGCGCGGAAACGTCATCGTCATCCTGCTTTGGGGTGGCGACAAGAGCACCCAACAAGGCGACATTCGAAAGGCC
AAGAAGCTGGCCGCCGATCTGGAGGATTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11206.85 Da        Isoelectric Point: 4.5463

>AT45241 WP_187301372.1 NZ_CP006371:28604-28924 [Aureimonas sp. AU20]
MVKISELEKYDAADVLETPEDRASYLSAALEDGNPVIIRKALQAVARSIGMKAVAEAAEVSRESLYRSLGEKGNPEFSTV
LKVMKAMGIGLAAIPISAEQAPSEAA

Download         Length: 321 bp

>AT45241 NZ_CP006371:28604-28924 [Aureimonas sp. AU20]
ATGGTCAAAATCAGCGAACTCGAAAAGTACGACGCTGCCGACGTCCTCGAAACACCCGAGGATCGCGCGAGCTATCTGTC
CGCAGCCCTGGAGGACGGAAATCCTGTCATCATCCGTAAGGCCCTGCAGGCCGTCGCTCGATCCATCGGTATGAAAGCGG
TCGCTGAGGCGGCCGAGGTGTCCCGCGAAAGCCTCTACCGATCGCTCGGTGAAAAGGGGAACCCTGAGTTCTCAACAGTT
CTGAAGGTCATGAAGGCGATGGGCATCGGGCTTGCAGCGATCCCGATCTCTGCAGAACAAGCCCCCTCGGAAGCAGCTTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References