Detailed information of TA system TA045238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhoH-LOG/-
• Location: 166557..168860
• Replicon: chromosome
• Accession: NZ_CP006270
• Organism: Synechococcus sp. KORDI-49 strain KORDI 49

Toxin (Protein)

• Gene name: PhoH
• Uniprot ID: -
• Locus tag: KR49_RS00920
• Protein ID: WP_043690771.1
• Coordinates: 166557..167945 (+)
• Length: 463 a.a.

Antitoxin (Protein)

• Gene name: LOG
• Uniprot ID: A0A076H7G2
• Locus tag: KR49_RS00925
• Protein ID: WP_043690772.1
• Coordinates: 167976..168860 (+)
• Length: 295 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KR49_RS00890	162950..163219	+	270	WP_043690761.1	hypothetical protein	-
KR49_RS00895	163264..163668	+	405	WP_043690764.1	hypothetical protein	-
KR49_RS00900	163698..164306	+	609	WP_043696395.1	hypothetical protein	-
KR49_RS00905	164324..164755	-	432	WP_043690766.1	type II toxin-antitoxin system VapC family toxin	-
KR49_RS00910	164752..165006	-	255	WP_043696399.1	Arc family DNA-binding protein	-
KR49_RS00915	165108..165950	-	843	WP_043690769.1	DUF429 domain-containing protein	-
KR49_RS00920	166557..167945	+	1389	WP_043690771.1	PhoH family protein	Toxin
KR49_RS00925	167976..168860	+	885	WP_043690772.1	LOG family protein	Antitoxin
KR49_RS00930	168868..169026	-	159	WP_162176145.1	hypothetical protein	-
KR49_RS14160	169088..169264	-	177	WP_173402110.1	hypothetical protein	-
KR49_RS00945	170297..171127	-	831	WP_052378116.1	M20/M25/M40 family metallo-hydrolase	-
KR49_RS00950	171369..172622	-	1254	WP_052378117.1	VWA domain-containing protein	-
KR49_RS00955	172646..173227	-	582	WP_043690782.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-150)

Antitoxin

• LOG family (153-281)

Sequences

Toxin

Protein

• Length: 463 a.a.
• Molecular weight: 50789.69 Da
• Isoelectric Point: 5.3335

>T45238 WP_043690771.1 NZ_CP006270:166557-167945 [Synechococcus sp. KORDI-49]
MKNKIVVLDTNVLLHDPEAPHRFGDLRVVIPMQVVEEIDRFKKDHSEKGRNARRISRLLDSYRARGSLADGVPIQGSDQG
ILQVIFCQTQALNELPAELQGGGGDNNILAVALEQMRCSGLKEAPEVVLISKDINLRIKADAVGLQAEDYINDNVSIDDL
YTGFRELSTDAETIKNLHDEEQLSLSAVTDAEGQHLQANEGVVMVDQHNDSHSLLARHQGNSNTIKPLHWLNRAHLGRIK
ARNREQSFALDLLLDPSIALVTLVGKAGTGKTLLALAAGLHQVADTHQYARLLVTRPPISLGKDIGYLPGTLEEKLGPWM
KPIIDNIDFLTGASPGEDADQTKIQRHREPRNAWADLQGMGLLEVEAINTIRGRSIPNQFLVVDEAQNLTPLEVKTIVTR
VGEGTKVVFTGDPYQIDNPYVDAESNGLTWLVEKLKGQPLVGHMTLTKGERSELAELAANIL

Nucleotide

• Length: 1389 bp

>T45238 NZ_CP006270:166557-167945 [Synechococcus sp. KORDI-49]
ATGAAAAACAAAATTGTCGTACTCGACACGAATGTGCTTCTCCATGACCCTGAGGCTCCACACCGCTTCGGAGATCTGAG
GGTTGTGATCCCCATGCAGGTGGTGGAAGAAATCGATCGCTTTAAAAAAGATCACTCTGAAAAAGGCAGGAATGCCCGGC
GGATTTCAAGGCTCCTGGATTCCTATCGCGCTCGCGGAAGCCTCGCTGATGGCGTTCCAATCCAGGGATCTGATCAGGGA
ATATTGCAAGTGATTTTCTGCCAGACCCAAGCCCTCAATGAATTACCGGCAGAGTTGCAGGGTGGGGGTGGTGACAACAA
CATTCTCGCGGTGGCCCTGGAGCAGATGCGATGCAGCGGGCTGAAAGAGGCGCCAGAGGTCGTCTTGATCAGCAAAGACA
TCAATCTGAGAATCAAAGCCGATGCGGTGGGTCTGCAAGCGGAGGACTACATCAACGACAATGTCTCGATTGATGATTTG
TACACGGGCTTCCGTGAACTCAGCACCGATGCGGAGACGATCAAGAACCTGCATGACGAGGAGCAACTTTCACTGTCAGC
AGTAACAGATGCCGAGGGGCAGCATCTCCAGGCCAATGAAGGCGTCGTGATGGTGGATCAGCACAACGACAGCCACAGCC
TGCTTGCCCGGCATCAAGGCAACAGCAACACCATCAAGCCGCTGCACTGGCTGAATCGGGCTCATTTGGGACGCATCAAG
GCGAGAAACCGCGAGCAAAGCTTCGCGCTTGATCTGCTGCTGGATCCATCCATCGCCCTGGTGACTCTGGTGGGCAAGGC
AGGCACAGGCAAAACGCTGCTGGCCCTGGCTGCCGGCTTGCACCAGGTGGCTGATACCCATCAATACGCACGCCTTCTGG
TGACGCGTCCGCCGATCTCACTCGGAAAAGACATTGGTTATCTGCCCGGCACGCTTGAGGAGAAGCTCGGGCCCTGGATG
AAGCCGATCATCGACAACATCGATTTCCTCACCGGTGCTTCACCTGGTGAGGATGCTGACCAGACGAAAATACAGCGGCA
TCGGGAACCACGCAACGCCTGGGCTGACCTTCAAGGCATGGGCTTGTTGGAGGTAGAAGCGATCAACACCATTCGTGGTC
GATCGATCCCCAATCAGTTTCTGGTGGTGGATGAGGCGCAAAACCTGACTCCCCTGGAAGTGAAGACGATCGTCACGCGG
GTGGGTGAAGGAACAAAGGTTGTGTTCACCGGTGATCCCTATCAAATCGACAACCCCTATGTGGATGCAGAAAGCAACGG
TCTCACCTGGTTGGTGGAAAAGCTCAAGGGTCAGCCTCTGGTGGGACACATGACCCTCACAAAGGGAGAGCGGAGTGAAC
TGGCTGAACTGGCTGCCAACATCCTCTGA

Antitoxin

Protein

• Length: 295 a.a.
• Molecular weight: 32608.95 Da
• Isoelectric Point: 5.3660

>AT45238 WP_043690772.1 NZ_CP006270:167976-168860 [Synechococcus sp. KORDI-49]
MPGFNDQSNGEQANLDAILKSSTYRIAHEDPDLLNSNAMRGVRMLLEITKPDLDLETAGVESTIIVFGGARIVDRETALK
GLEEAERCLSENPGSSTLKRQVAHAEHRVVLSRFYDLAREFARLASQHGQANHKQCHGCASHVIVTGGGPGIMEAANRGA
FEAGCRSIGLNITLPFEQHPNPYITPDLCFRFNYFSLRKFHFVMRSVGAILFPGGFGTLDELFELLTLRQVGTKGSMPIV
LFGTEFWTKLVNFDYLAEMGLISNDDLDLIHFSDTAEEAWNFIRSQTLAEPEKS

Nucleotide

• Length: 885 bp

>AT45238 NZ_CP006270:167976-168860 [Synechococcus sp. KORDI-49]
ATGCCTGGATTCAATGATCAATCCAATGGCGAGCAAGCCAATCTGGATGCCATTCTGAAATCATCGACCTACCGAATTGC
CCATGAAGATCCTGATTTGTTGAACAGCAATGCCATGCGCGGTGTGCGCATGCTGCTTGAAATCACCAAGCCTGATCTGG
ATCTGGAAACAGCTGGTGTGGAATCAACCATCATTGTTTTTGGCGGCGCCAGAATTGTCGATCGAGAGACTGCACTCAAG
GGATTGGAGGAAGCAGAGCGATGCCTGAGCGAAAACCCAGGCTCATCAACGTTGAAGCGACAAGTCGCCCACGCTGAACA
CCGCGTCGTGTTGTCTCGTTTTTATGATTTGGCCCGAGAATTTGCCCGCCTAGCCTCCCAGCATGGCCAGGCGAATCACA
AACAATGCCATGGATGCGCATCGCATGTGATCGTGACCGGCGGTGGGCCGGGAATCATGGAAGCAGCCAACCGTGGCGCC
TTTGAAGCCGGTTGCCGTTCCATCGGGCTCAATATCACTCTCCCGTTTGAACAGCACCCCAATCCCTACATCACGCCTGA
TCTTTGTTTCCGGTTCAATTACTTTTCACTTCGCAAATTTCACTTTGTGATGCGTTCCGTCGGGGCCATCCTGTTTCCAG
GGGGCTTTGGCACGCTTGATGAGCTCTTTGAGCTCCTCACCTTGCGGCAGGTCGGCACCAAGGGGAGCATGCCAATCGTG
CTGTTCGGTACAGAGTTCTGGACCAAACTTGTGAACTTTGACTACCTCGCCGAGATGGGTTTGATTTCAAATGATGATCT
CGATCTGATTCATTTTTCAGACACGGCAGAGGAGGCCTGGAACTTCATCCGCAGCCAGACGCTGGCTGAGCCTGAGAAAA
GCTGA

Structures

Antitoxin

• AlphaFold DB: A0A076H7G2