Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5236157..5236989 Replicon chromosome
Accession NZ_CP006262
Organism Escherichia coli O145:H28 str. RM13516

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag ECRM13516_RS26425 Protein ID WP_000854753.1
Coordinates 5236615..5236989 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag ECRM13516_RS26420 Protein ID WP_001315620.1
Coordinates 5236157..5236525 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRM13516_RS26385 5232993..5233448 + 456 WP_000581504.1 hypothetical protein -
ECRM13516_RS26390 5233527..5233760 + 234 WP_001119729.1 DUF905 family protein -
ECRM13516_RS26395 5233860..5234678 + 819 WP_001234620.1 DUF945 domain-containing protein -
ECRM13516_RS26400 5234733..5235218 + 486 WP_000849588.1 antirestriction protein -
ECRM13516_RS26405 5235234..5235710 + 477 WP_001560709.1 RadC family protein -
ECRM13516_RS26410 5235773..5235994 + 222 WP_000692345.1 DUF987 domain-containing protein -
ECRM13516_RS26420 5236157..5236525 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECRM13516_RS26425 5236615..5236989 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
ECRM13516_RS26430 5236986..5237474 + 489 WP_000777547.1 hypothetical protein -
ECRM13516_RS26435 5237486..5237683 + 198 WP_000839281.1 DUF957 domain-containing protein -
ECRM13516_RS32615 5237768..5237965 + 198 WP_025380687.1 hypothetical protein -
ECRM13516_RS26445 5237980..5238405 + 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
ECRM13516_RS26450 5238402..5238752 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
ECRM13516_RS26455 5238783..5240396 + 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T45231 WP_000854753.1 NZ_CP006262:5236615-5236989 [Escherichia coli O145:H28 str. RM13516]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T45231 NZ_CP006262:5236615-5236989 [Escherichia coli O145:H28 str. RM13516]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT45231 WP_001315620.1 NZ_CP006262:5236157-5236525 [Escherichia coli O145:H28 str. RM13516]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT45231 NZ_CP006262:5236157-5236525 [Escherichia coli O145:H28 str. RM13516]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References