Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1070743..1071224 Replicon chromosome
Accession NZ_CP006262
Organism Escherichia coli O145:H28 str. RM13516

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag ECRM13516_RS05140 Protein ID WP_021568727.1
Coordinates 1070743..1071033 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag ECRM13516_RS05145 Protein ID WP_000108762.1
Coordinates 1071033..1071224 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRM13516_RS05110 1065854..1066096 - 243 WP_000273151.1 DUF4224 domain-containing protein -
ECRM13516_RS05115 1066164..1068599 - 2436 WP_025380290.1 exonuclease -
ECRM13516_RS05120 1068693..1068884 - 192 WP_001098307.1 DUF1482 family protein -
ECRM13516_RS05125 1068881..1069069 - 189 WP_000413705.1 cell division inhibition protein DicB -
ECRM13516_RS05130 1069773..1070219 + 447 WP_025380291.1 hypothetical protein -
ECRM13516_RS05135 1070318..1070470 - 153 WP_000367377.1 DUF1391 family protein -
ECRM13516_RS05140 1070743..1071033 - 291 WP_021568727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECRM13516_RS05145 1071033..1071224 - 192 WP_000108762.1 hypothetical protein Antitoxin
ECRM13516_RS05150 1071242..1071742 - 501 WP_025380292.1 helix-turn-helix transcriptional regulator -
ECRM13516_RS05160 1072111..1072536 + 426 WP_025380293.1 Rha family transcriptional regulator -
ECRM13516_RS05165 1072608..1073714 + 1107 WP_025380294.1 hypothetical protein -
ECRM13516_RS05170 1073721..1074467 + 747 WP_000788759.1 ATP-binding protein -
ECRM13516_RS05175 1074489..1075259 + 771 WP_000451007.1 DUF1627 domain-containing protein -
ECRM13516_RS05180 1075275..1075688 + 414 WP_001151233.1 DUF977 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11105.96 Da        Isoelectric Point: 9.9854

>T45203 WP_021568727.1 NZ_CP006262:c1071033-1070743 [Escherichia coli O145:H28 str. RM13516]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLSEHPYLYPPSERALGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T45203 NZ_CP006262:c1071033-1070743 [Escherichia coli O145:H28 str. RM13516]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTTCTGAACACCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7075.91 Da        Isoelectric Point: 4.0270

>AT45203 WP_000108762.1 NZ_CP006262:c1071224-1071033 [Escherichia coli O145:H28 str. RM13516]
MSTVLSPIISEFETIEQENSYNEWLRTKVAASLADPRPAIPHDEVMAEMENLIAQIASTNRSE

Download         Length: 192 bp

>AT45203 NZ_CP006262:c1071224-1071033 [Escherichia coli O145:H28 str. RM13516]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References